Faculty of Health, Engineering and Science
School: Exercise and Health Sciences
This unit information may be updated and amended immediately prior to semester. To ensure you have the correct outline, please check it again at the beginning of semester.
Unit Title
Metabolic BiochemistryUnit Code
NUT2211Year
2015Enrolment Period
1Version
2Credit Points
15Full Year Unit
N
Mode of Delivery
On Campus
Description
This unit is designed to integrate the biochemistry and pathophysiology of disease in relation to nutritional and other clinical implications for treatment. The interplay between disease and the major metabolic pathways is emphasized for the major organ systems in the human body.
Prerequisite Rule
(Students must pass 1 units from SCC1226 AND Students must pass 1 units from SCH1134, SCH1143)
Learning Outcomes
On completion of this unit students should be able to:
- Apply this understanding to synthesise recent literature pertaining to a comprehensive review on the biochemical basis of nutritional therapy for diabetes, cardiovascular, renal, pulmonary and hepatic diseases, and metastatic cancers.
- Critically analyse diagnostic procedures and therapeutic clinical interventions in relation to common chronic diseases.
- Explain the biochemistry and pathophysiology of diabetes, cardiovascular, renal, pulmonary and hepatic diseases and analyse the implications for nutritional treatment and monitoring.
- Explain the biochemistry and pathophysiology of selected metabolic metastatic cancers and analyse the implications for nutritional treatment and monitoring.
- Explain the regulatory mechanisms of metabolic control and how they are influenced in disease by pharmacological and nutritional interventions.
- Identify the central reactions in energy metabolism, explaining how changes in the control and regulation of these biochemical reactions have implications for health and disease.
Unit Content
- Metabolic pathway regulation by allosteric, covalent modification and enzyme inhibition; endogenous and exogenous influences.
- Mitochondrial and cytoplasmic metabolism; details of how disease can impact upon their molecular control.
- The biochemistry and pathophysiology of cystic fibrosis and the implications for ameliorating exocrine pancreatic function.
- The biochemistry and pathophysiology of diabetes in relation to therapies to modify cellular biochemical function.
- The biochemistry and pathophysiology of hepatic disease, including inflammation, necrosis, regeneration and cirrhosis.
- The biochemistry and pathophysiology of myocardial infarction.
- The biochemistry and pathophysiology of renal dysfunction from stages 1 to 4 of function.
- The biochemistry, pathophysiology and generation of plasma markers in the major cancers of the gastrointestinal tract and bone.
- The biomarkers of selected chronic diseases and the nutritional implications for treatment.
Additional Learning Experience Information
Lectures supported by audiovisual material and laboratory sessions supported by audiovisual material, computer software and e-Learning activities. Students will work in small teams as part of their laboratory training.
Assessment
GS1 GRADING SCHEMA 1 Used for standard coursework units
Students please note: The marks and grades received by students on assessments may be subject to further moderation. All marks and grades are to be considered provisional until endorsed by the relevant Board of Examiners.
Due to the professional competency skill development associated with this Unit, student attendance/participation within listed in-class activities is compulsory. Students failing to meet participation standards as outlined in the unit plan may be awarded an I Grade (Fail - incomplete). Students who are unable to meet this requirement for medical or other reasons must seek the approval of the unit coordinator.
ON CAMPUS| Type | Description | Value |
|---|
| Assignment | Literature review | 20% |
| Test | Mid-semester test | 30% |
| Examination | End of semester examination | 50% |
Text References
- ^ Nelson, D.L., & Cox, M.M. (2012). Lehninger principles of biochemistry (6th ed.). New York, NY: W.H. Freeman and Co.
- Campbell, M.K., & Farrell, S.O. (2009). Biochemistry (6th ed.). Florida, FL: Harcourt Brace College Publishing.
- Marangoni, A.G. (2003). Enzyme kinetics: A modern approach. Hoboken, NJ: H.J. Wiley.
- Mathews, C.K., van Holde, K.E., Appling, D.R., & Anthony-Cahill, S.J. (2012). Biochemistry (4th ed.). New York, NY: Prentice-Hall.
Journal References
- Perry, C.G., Kane, D.A., Lanza, I.R., & Neufer, P.D. (2013). Diabetes. 62 Methods for Assessing Mitochondrial Function in Diabetes 1041-1053. Note: Further relevant journal articles will be provided during the course of teaching.
- Wu, M., Neilson, A., Swift, A.L., Moran, R., Tamagine, J., Parslow, D., ... Ferrick, D.A. (2007). American Journal of Physiology, Cell Physiology. 292. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells C125-C136.
Website References
^ Mandatory reference
Disability Standards for Education (Commonwealth 2005)
For the purposes of considering a request for Reasonable Adjustments under the Disability Standards for Education (Commonwealth 2005), inherent requirements for this subject are articulated in the Unit Description, Learning Outcomes and Assessment Requirements of this entry. The University is dedicated to provide support to those with special requirements. Further details on the support for students with disabilities or medical conditions can be found at the Access and Inclusion website.
Academic Misconduct
Edith Cowan University has firm rules governing academic misconduct and there are substantial penalties that can be applied to students who are found in breach of these rules. Academic misconduct includes, but is not limited to:
- plagiarism;
- unauthorised collaboration;
- cheating in examinations;
- theft of other students' work;
Additionally, any material submitted for assessment purposes must be work that has not been submitted previously, by any person, for any other unit at ECU or elsewhere.
The ECU rules and policies governing all academic activities, including misconduct, can be accessed through the ECU website.
NUT2211|2|1
Faculty of Health, Engineering and Science
School: Exercise and Health Sciences
This unit information may be updated and amended immediately prior to semester. To ensure you have the correct outline, please check it again at the beginning of semester.
Unit Title
Metabolic BiochemistryUnit Code
NUT2211Year
2015Enrolment Period
2Version
2Credit Points
15Full Year Unit
N
Mode of Delivery
On Campus
Description
This unit is designed to integrate the biochemistry and pathophysiology of disease in relation to nutritional and other clinical implications for treatment. The interplay between disease and the major metabolic pathways is emphasized for the major organ systems in the human body.
Prerequisite Rule
(Students must pass 1 units from SCC1226 AND Students must pass 1 units from SCH1134, SCH1143)
Learning Outcomes
On completion of this unit students should be able to:
- Apply this understanding to synthesise recent literature pertaining to a comprehensive review on the biochemical basis of nutritional therapy for diabetes, cardiovascular, renal, pulmonary and hepatic diseases, and metastatic cancers.
- Critically analyse diagnostic procedures and therapeutic clinical interventions in relation to common chronic diseases.
- Explain the biochemistry and pathophysiology of diabetes, cardiovascular, renal, pulmonary and hepatic diseases and analyse the implications for nutritional treatment and monitoring.
- Explain the biochemistry and pathophysiology of selected metabolic metastatic cancers and analyse the implications for nutritional treatment and monitoring.
- Explain the regulatory mechanisms of metabolic control and how they are influenced in disease by pharmacological and nutritional interventions.
- Identify the central reactions in energy metabolism, explaining how changes in the control and regulation of these biochemical reactions have implications for health and disease.
Unit Content
- Metabolic pathway regulation by allosteric, covalent modification and enzyme inhibition; endogenous and exogenous influences.
- Mitochondrial and cytoplasmic metabolism; details of how disease can impact upon their molecular control.
- The biochemistry and pathophysiology of cystic fibrosis and the implications for ameliorating exocrine pancreatic function.
- The biochemistry and pathophysiology of diabetes in relation to therapies to modify cellular biochemical function.
- The biochemistry and pathophysiology of hepatic disease, including inflammation, necrosis, regeneration and cirrhosis.
- The biochemistry and pathophysiology of myocardial infarction.
- The biochemistry and pathophysiology of renal dysfunction from stages 1 to 4 of function.
- The biochemistry, pathophysiology and generation of plasma markers in the major cancers of the gastrointestinal tract and bone.
- The biomarkers of selected chronic diseases and the nutritional implications for treatment.
Additional Learning Experience Information
Lectures supported by audiovisual material and laboratory sessions supported by audiovisual material, computer software and e-Learning activities. Students will work in small teams as part of their laboratory training.
Assessment
GS1 GRADING SCHEMA 1 Used for standard coursework units
Students please note: The marks and grades received by students on assessments may be subject to further moderation. All marks and grades are to be considered provisional until endorsed by the relevant Board of Examiners.
Due to the professional competency skill development associated with this Unit, student attendance/participation within listed in-class activities is compulsory. Students failing to meet participation standards as outlined in the unit plan may be awarded an I Grade (Fail - incomplete). Students who are unable to meet this requirement for medical or other reasons must seek the approval of the unit coordinator.
ON CAMPUS| Type | Description | Value |
|---|
| Assignment | Literature review | 20% |
| Test | Mid-semester test | 30% |
| Examination | End of semester examination | 50% |
Text References
- ^ Nelson, D.L., & Cox, M.M. (2012). Lehninger principles of biochemistry (6th ed.). New York, NY: W.H. Freeman and Co.
- Marangoni, A.G. (2003). Enzyme kinetics: A modern approach. Hoboken, NJ: H.J. Wiley.
- Mathews, C.K., van Holde, K.E., Appling, D.R., & Anthony-Cahill, S.J. (2012). Biochemistry (4th ed.). New York, NY: Prentice-Hall.
- Campbell, M.K., & Farrell, S.O. (2009). Biochemistry (6th ed.). Florida, FL: Harcourt Brace College Publishing.
Journal References
- Perry, C.G., Kane, D.A., Lanza, I.R., & Neufer, P.D. (2013). Diabetes. 62 Methods for Assessing Mitochondrial Function in Diabetes 1041-1053. Note: Further relevant journal articles will be provided during the course of teaching.
- Wu, M., Neilson, A., Swift, A.L., Moran, R., Tamagine, J., Parslow, D., ... Ferrick, D.A. (2007). American Journal of Physiology, Cell Physiology. 292. Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells C125-C136.
Website References
^ Mandatory reference
Disability Standards for Education (Commonwealth 2005)
For the purposes of considering a request for Reasonable Adjustments under the Disability Standards for Education (Commonwealth 2005), inherent requirements for this subject are articulated in the Unit Description, Learning Outcomes and Assessment Requirements of this entry. The University is dedicated to provide support to those with special requirements. Further details on the support for students with disabilities or medical conditions can be found at the Access and Inclusion website.
Academic Misconduct
Edith Cowan University has firm rules governing academic misconduct and there are substantial penalties that can be applied to students who are found in breach of these rules. Academic misconduct includes, but is not limited to:
- plagiarism;
- unauthorised collaboration;
- cheating in examinations;
- theft of other students' work;
Additionally, any material submitted for assessment purposes must be work that has not been submitted previously, by any person, for any other unit at ECU or elsewhere.
The ECU rules and policies governing all academic activities, including misconduct, can be accessed through the ECU website.
NUT2211|2|2
