Handbook : Unit informationEdith Cowan University

School: Medical and Health Sciences

This unit information may be updated and amended immediately prior to semester. To ensure you have the correct outline, please check it again at the beginning of semester.

• Unit Title

  Metabolic Biochemistry

• Unit Code

  NUT2211

• Year

  2017

• Enrolment Period

  2

• Version

  2

• Credit Points

  15

• Full Year Unit

  N

• Mode of Delivery

  On Campus
  

• Unit Coordinator

  Dr Claus Thagaard CHRISTOPHERSEN

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Description

This unit is designed to integrate the biochemistry and pathophysiology of disease in relation to nutritional and other clinical implications for treatment. The interplay between disease and the major metabolic pathways is emphasized for the major organ systems in the human body.

Prerequisite Rule

(Students must pass 1 units from SCC1226 AND Students must pass 1 units from SCH1134, SCH1143)

Learning Outcomes

On completion of this unit students should be able to:

1. Apply this understanding to synthesise recent literature pertaining to a comprehensive review on the biochemical basis of nutritional therapy for diabetes, cardiovascular, renal, pulmonary and hepatic diseases, and metastatic cancers.
2. Critically analyse diagnostic procedures and therapeutic clinical interventions in relation to common chronic diseases.
3. Explain the biochemistry and pathophysiology of diabetes, cardiovascular, renal, pulmonary and hepatic diseases and analyse the implications for nutritional treatment and monitoring.
4. Explain the biochemistry and pathophysiology of selected metabolic metastatic cancers and analyse the implications for nutritional treatment and monitoring.
5. Explain the regulatory mechanisms of metabolic control and how they are influenced in disease by pharmacological and nutritional interventions.
6. Identify the central reactions in energy metabolism, explaining how changes in the control and regulation of these biochemical reactions have implications for health and disease.

Unit Content

1. Metabolic pathway regulation by allosteric, covalent modification and enzyme inhibition; endogenous and exogenous influences.
2. Mitochondrial and cytoplasmic metabolism; details of how disease can impact upon their molecular control.
3. The biochemistry and pathophysiology of cystic fibrosis and the implications for ameliorating exocrine pancreatic function.
4. The biochemistry and pathophysiology of diabetes in relation to therapies to modify cellular biochemical function.
5. The biochemistry and pathophysiology of hepatic disease, including inflammation, necrosis, regeneration and cirrhosis.
6. The biochemistry and pathophysiology of myocardial infarction.
7. The biochemistry and pathophysiology of renal dysfunction from stages 1 to 4 of function.
8. The biochemistry, pathophysiology and generation of plasma markers in the major cancers of the gastrointestinal tract and bone.
9. The biomarkers of selected chronic diseases and the nutritional implications for treatment.

Additional Learning Experience Information

Lectures supported by audiovisual material and laboratory sessions supported by audiovisual material, computer software and e-Learning activities. Students will work in small teams as part of their laboratory training.

Assessment

GS1 GRADING SCHEMA 1 Used for standard coursework units

Students please note: The marks and grades received by students on assessments may be subject to further moderation. All marks and grades are to be considered provisional until endorsed by the relevant Board of Examiners.

Due to the professional competency skill development associated with this Unit, student attendance/participation within listed in-class activities and/or online activities including discussion boards is compulsory. Students failing to meet participation standards as outlined in the unit plan may be awarded an I Grade (Fail - incomplete). Students who are unable to meet this requirement for medical or other reasons must seek the approval of the unit coordinator.

Core Reading(s)

• Nelson, D. L., & Cox, M. M. (2013). Lehninger principles of biochemistry (6th ed.). New York, NY: W.H. Freeman and Co.

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