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    Eleanore Daines

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Investigating interactions between genetic variation and physical activity differences in Alzheimer's Disease

Student name:

Eleanore Daines (Masters by Research candidate)

Supervisors:

  1. Dr Tenielle Porter
  2. Professor Simon Laws
  3. Dr Eleanor O'Brien

Summary of thesis:

Metabolic clearance pathways are a promising area of research into possibly mitigating the progression of Alzheimer’s Disease. An alternative clearance pathway to the Glymphatic system is autophagy. Physical activity regulates the metabolic state and activates autophagy through activation of AMPK-ULK1 pathway, upregulation of TFEB and activation of SIRT1. Genetic variance within specific genes may influence the relationship between metabolic clearance, physical activity, and progression of Alzheimer’s Disease. This project will aim to identify any significant relationship between genetic variance in metabolic clearance pathways, physical activity, and Alzheimer’s Disease progression.

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