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  • Image showing HDR student Tharani Senavirathna

    Tharani Senavirathna

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Efficacy of ellegic acid and its microbial metabolites in a diet-induced model of Non-alcoholic Steatohepatitis (NASH)

Student name:

Tharani Senavirathna (PhD candidate)

Supervisors:

1. Dr Lois Balmer
2. Dr Ricky Lareu (Curtin University)
3. Dr Ari Shafaei Darestani

Summary of thesis:

This project investigates the role of a nutraceutical on Non Alcoholic Steatohepatitis (NASH) and
beyond. This project aims to improve, with animal and then patient studies, patient outcome with
NASH. Liver disease up to a certain point is reversible, the only way to identify the severity of liver
disease is via biopsy which is invasive. The current project is in an animal model, once confirmed that
we have a nutraceutical that is able to halt or reverse severe liver disease we hope to move toward
the development of improved diagnostic metabolic and IgG N-glycosylation profiles) and tailored
intervention strategies (the nutraceutical intervention).

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