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    Sharon Chen

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Investigating roles of IgG N-glycosylation in insulin resistance mediated by adipose tissue inflammation

Student name:

Sharon Chen (PhD candidate)

Supervisors:

1. Professor Wei Wang
2. Dr Lois Balmer
3. Dr Manshu Song
4. Dr Yongsong Chen (Shantou University, China)

Summary of thesis:

Insulin resistance is a common pathological feature of obesity and type 2 diabetes mellitus (T2DM), but the mechanisms remain poorly understood. Immunoglobulin G (IgG) is involved in adipose tissue inflammation, which is considered a major driver in reducing insulin sensitivity. The IgG N-glycosylation profiles, which have shown association with obesity and T2DM, may be associated with insulin resistance. Thus, this project aims to validate the potential association between IgG N-glycosylation profiles and insulin resistance, and to illustrate the specificity and sensitivity of IgG N-glycosylation profiles as potentially dynamic biomarkers for a future routine diagnostic and prophylactic test for insulin resistance.

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