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  • Dr Andrew J Woo

    Dr Andrew J Woo

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Dr Andrew J Woo

Lecturer

Staff Member Details
Telephone: +61 8 6304 5684
Email: a.woo@ecu.edu.au
Campus: Joondalup  
Room: JO21.505  
ORCID iD: https://orcid.org/0000-0003-1198-6373

Andrew is a Lecturer in Biomedical Sciences in the School of Medical and Health Sciences.

Current Teaching

  • SCH2232 Medical Biochemistry
  • SCH3244 Development Biology

Background

  • 2020 - Present : Lecturer and Unit Co-ordinator, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA
  • 2012 - Present : Research Fellow, Harry Perkins Institute of Medical Research, University of Western Australia, Perth, WA
  • 2004 - 2012      : Postdoctoral Research Fellow, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA

Professional Associations

  • International Member, American Society of Haematology (ASH)
  • Member, International Society for Stem Cell Research (ISSCR)
  • Member, Australian Society for Medical Research (ASMR)

Awards and Recognition

  • 2021 : WA NHMRC Near-miss Awards (WANMA)
  • 2016 : WA NHMRC Near-miss Awards (WANMA)
  • 2012 : RPH Medical Research Foundation Fellowship Award

Research Areas and Interests

Andrew is a biomedical scientist with an extensive international research experience in developmental haematopoiesis, blood disorders, cancers, and stem cells.

His research focuses on understanding the gene regulatory network in normal and diseased cells, finding druggable targets to alleviate symptoms of diseases such as cancers and blood disorders. Throughout his career, he has attracted over AUD 700K in research grants as a lead investigator and published numerous scientific articles in the field, including in Cell, Journal of Clinical Investigation, Blood, Cancer Cell, Molecular Cell and Nature Communications.

Andrew is currently looking to recruit postgraduate students to work on:

1. Targeting breast cancer stem cells for therapy

2. Cellular reprogramming to generate platelets for transfusion

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2004.

Research Outputs

2022

Journal Articles

  • Kim, M., Singh, M., Lee, BL., Hibbs, M., Richardson, K., Ellies, L., Wintle, L., Stuart, L., Wang, JY., Voon, DC., Blancafort, P., Wang, J., Kim, J., Leedman, PJ., Woo, A. (2022). A MYC-ZNF148-ID1/3 regulatory axis modulating cancer stem cell traits in aggressive breast cancer. Oncogenesis, 11(1), Article number 60. https://doi.org/10.1038/s41389-022-00435-1.
  • McGrath, F., Francis, A., Fatovich, D., Macdonald, S., Arendts, G., Woo, A., Bosio, E. (2022). Genes involved in platelet aggregation and activation are downregulated during acute anaphylaxis in humans. Clinical & Translational Immunology, 11(12), article number e1435. https://doi.org/10.1002/cti2.1435.

2021

Journal Articles

  • Beveridge, D., Richardson , K., Epis, M., Brown, R., Stuart, L., Woo, A., Leedman, P. (2021). The tumor suppressor miR-642a-5p targets Wilms Tumor 1 gene and cell-cycle progression in prostate cancer. Scientific Reports, 11(December 2021), Article number 18003. https://doi.org/10.1038/s41598-021-97190-x.
  • McGrath, F., Francis, A., Fatovich, D., Macdonald, S., Arendts, G., Bosco, A., Woo, A., Bosio, E. (2021). Small nucleolar RNA networks are up-regulated during human anaphylaxis. Clinical and Experimental Allergy, 51(10), 1310-1321. https://doi.org/10.1111/cea.13982.
  • Golden, E., Rashwan, R., Woodward , EA., Sgro , A., Wang, E., Sorolla, A., Waryah, C., Tie , WJ., Cuyàs, E., Ratajska, M., Kardaś, I., Kozlowski, P., Johnstone, E., See, H., Duffy , C., Parry, J., Lagerborg, K., Czapiewski, P., Menendez, J., Gorczyński, A., Wasag, B., Pfleger , K., Curtis, C., Lee, B., Kim, J., Cursons , J., Pavlos, N., Biernat, W., Jain, M., Woo, A., Redfern, A., Blancafort, P. (2021). The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. Nature Communications, 12(1), Article number 1920. https://doi.org/10.1038/s41467-021-22101-7.

2020

Journal Articles

  • Salik, B., Yi, H., Hassan, N., Santiappillai, N., Vick, B., Connerty, P., Duly, A., Trahair, T., Woo, A., Beck, D., Liu, T., Spiekermann, K., Jeremias, I., Wang, J., Kavallaris, M., Haber, M., Norris, MD., Liebermann, DA., D'andrea, RJ., Murriel, C., Wang, JY. (2020). Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia. Cancer Cell, 38(2), 263-278.e6. https://doi.org/10.1016/j.ccell.2020.05.014.

2019

Journal Articles

  • Lynch, JR., Salik, B., Connerty, P., Vick, B., Leung, H., Pijning, A., Jeremias, I., Spiekermann, K., Trahair, T., Liu, T., Haber, M., Norris, MD., Woo, A., Hogg, P., Wang, J., Wang, JY. (2019). JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis. Leukemia, 33(6), 1400-1410. https://doi.org/10.1038/s41375-018-0354-z.
  • Woo, A., Patry, CA., Ghamari, A., Pregernig, G., Yuan, D., Zheng, K., Piers, T., Hibbs, M., Li, JK., Fidalgo, M., Wang, JY., Lee, J., Leedman, P., Wang, J., Fraenkel, E., Cantor, AB. (2019). Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood Advances, 3(16), 2499-2511. https://doi.org/10.1182/bloodadvances.2018030551.
  • Gonzales-Aloy, E., Connerty, P., Salik, B., Liu, B., Woo, A., Haber, M., Norris, MD., Wang, J., Wang, JY. (2019). MiR-101 suppresses the development of MLL-rearranged acute myeloid leukemia. Haematologica: the hematology journal, 104(7), e296-e299. https://doi.org/10.3324/haematol.2018.209437.
  • Wang, E., Sorolla, A., Cunningham, PT., Bogdawa, HM., Beck, S., Golden, E., Dewhurst, RE., Florez, L., Cruickshank, MN., Hoffmann, K., Hopkins, RM., Kim, J., Woo, A., Watt, PM., Blancafort, P. (2019). Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers. Oncogene, 38(1), 140-150. https://doi.org/10.1038/s41388-018-0421-y.

2014

Journal Articles

  • Beck, S., Lee, B., Rhee, C., Song, J., Woo, A., Kim, J. (2014). CpG island-mediated global gene regulatory modes in mouse embryonic stem cells. Nature Communications, 5(5490), 1-12.

2013

Journal Articles

  • Das , P., Shao, Z., Beyaz, S., Apostolou, E., Pinello, L., Los Angeles, A., O’brien, K., Atsma , J., Fujiwara, Y., Nguyen, M., Ljuboja , D., Guo, G., Woo, A., Yuan, G., Onder, T., Daley, G., Hochedlinger, K., Kim, J., Orkin, S. (2013). Distinct and Combinatorial Functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in Mouse Embryonic Stem Cell Identity. Molecular Cell, 53(January 9, 2014), 32-48.

Research Projects

  • Identifying a novel ovarian cancer oncogene for diagnosis and treatment, Cancer Council of WA Inc, Student Vacation Research Scholarship, 2023 ‑ 2024, $3,000.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Doctor of Philosophy, Elucidating the molecular actions of thyroid hormone receptor beta in breast cancer

Completed Supervisions

Co-principal Supervisor

  • Master of Medical and Health Science by Research, Thyroid hormone receptor beta is an oncogene in triple negative subtype of breast cancer
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