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Dr Eugene Hone

Post Doctoral Research Fellow

Staff Member Details
Email: e.hone@ecu.edu.au
ORCID iD: https://orcid.org/0000-0001-6708-3718

Eugene is a Post Doctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.

Qualifications

  • Doctor of Philosophy, The University of Western Australia, 2010.

Research Outputs

2024

Journal Articles

  • Poudel, P., Frost, SM., Eslick, S., Sohrabi, H., Taddei, K., Martins, R., Hone, E. (2024). Hyperspectral Retinal Imaging as a Non-Invasive Marker to Determine Brain Amyloid Status. Journal of Alzheimer's Disease, 100(2024), S131-S152. https://doi.org/10.3233/JAD-240631.
  • Savar, SM., Ma, B., Hone, E., Jahan, F., Markovic, S., Pedrini, S., Shemehsavar, S., Easwaran, V., Taddei, K., Gardener, S., Chhatwal, JP., Van Etten, ES., Van Osch, MJ., Clarke, D., Gnjec, A., Van Buchem, MA., Wermer, MJ., Hankey, GJ., Greenberg, SM., Martins, R., Sohrabi, H. (2024). Fluid biomarkers in cerebral amyloid angiopathy. Frontiers in Neuroscience, 18(2024), article number 1347320. https://doi.org/10.3389/fnins.2024.1347320.

2022

Journal Articles

  • Jayatunga, D., Hone, E., Fernando, B., Garg, , ML., Verdile, , G., Martins, R. (2022). Mitoprotective Effects of a Synergistic Nutraceutical Combination: Basis for a Prevention Strategy Against Alzheimer's Disease.. Frontiers in Aging Neuroscience, 13(21 February 2022), Article number 781468. https://doi.org/10.3389/fnagi.2021.781468.
  • Chatterjee, P., Pedrini, S., Ashton, N., Tegg, M., Goozee, K., Singh, A., Karikari, T., Simrén, J., Vanmechelen, E., Armstrong, N., Hone, E., Asih, P., Taddei, K., Doré, V., Villemagne, V., Sohrabi, H., Zetterberg, H., Masters, C., Blennow, K., Martins, R. (2022). Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease. Alzheimer's and Dementia, 18(6), 1141-1154. https://doi.org/10.1002/alz.12447.
  • Thota, R., Chatterjee, P., Pedrini, S., Hone, E., Ferguson, J., Garg, M., Martins, R. (2022). Association of Plasma Neurofilament Light Chain With Glycaemic Control and Insulin Resistance in Middle-Aged Adults. Frontiers in Endocrinology, 13(2022), article number 915449. https://doi.org/10.3389/fendo.2022.915449.
  • Pedrini, S., Chatterjee, P., Nakamura, A., Tegg, M., Hone, E., Rainey-Smith, S., Rowe, C., Dore, V., Villemagne, V., Ames, D., Kaneko, N., Kirby, S., Taddei, K., Fernando, B., Martins, I., Bharadwaj, P., Sohrabi, H., Masters, C., Brown, B., Martins, R. (2022). The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults. Frontiers in Aging Neuroscience, 14(2022), article number 771214. https://doi.org/10.3389/fnagi.2022.771214.
  • Jayatunga, D., Hone, E., Fernando, B., Garg, , ML., Verdile, , G., Martins, R. (2022). A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease.. Frontiers in Aging Neuroscience, 14(16 February 2022), Article number 780602. https://doi.org/10.3389/fnagi.2022.780602.
  • Pedrini, S., Doecke, J., Hone, E., Wang, P., Thota, R., Bush, A., Rowe, C., Dore, V., Villemagne, V., Ames, D., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Taddei, K., Gandy, S., Masters, C., Chatterjee, P., Martins, R. (2022). Plasma high-density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume. Journal of Neurochemistry, 163(1), 53-67. https://doi.org/10.1111/jnc.15681.

2021

Journal Articles

  • Rezaee, N., Fernando, B., Hone, E., Sohrabi, H., Johnson, S., Gunzburg, S., Martins, R. (2021). Potential of sorghum polyphenols to prevent and treat Alzheimer’s disease. Frontiers in Aging Neuroscience, 13(Oct 2021), Article number 729949. https://doi.org/10.3389/fnagi.2021.729949.
  • Jayatunga, P., Hone, E., Khaira, H., Lunelli, T., Singh, H., Guillemin, G., Fernando, B., Garg, M., Verdile, G., Martins, R. (2021). Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer’s Disease. Nutrients, 13(11), article number 3744. https://doi.org/10.3390/nu13113744.
  • Pedrini, S., Chatterjee, P., Hone, E., Martins, R. (2021). High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease. Journal of Neurochemistry, 159(2), 343-377. https://doi.org/10.1111/jnc.15170.
  • Roe, J., Vidal-Piñeiro, D., Sørensen, ., Brandmaier, A., Düzel, S., Gonzalez, H., Kievit, R., Knights, E., Kühn, S., Lindenberger, U., Mowinckel, A., Nyberg, L., Park, D., Pudas, S., Rundle, M., Walhovd, K., Fjell, A., Westerhausen, R., Masters, C., Bush, A., Fowler, C., Darby, D., Pertile, K., Restrepo, C., Roberts, B., Robertson, J., Rumble, R., Ryan, T., Collins, S., Thai, C., Trounson, B., Lennon, K., Li, Q., Ugarte, F., Volitakis, I., Vovos, M., Williams, R., Baker, J., Russell, A., Peretti, M., Milicic, L., Lim, L., Rodrigues, M., Taddei, K., Taddei, T., Hone, E., Lim, F., Fernandez, S., Rainey-Smith, S., Pedrini, S., Martins, R., Doecke, J., Bourgeat, P., Fripp, J., Gibson, S., Leroux, H., Hanson, D., Dore, V., Zhang, P., Burnham, S., Rowe, C., Villemagne, V., Yates, P., Pejoska, S., Jones, G., Ames, D., Cyarto, E., Lautenschlager, N., Barnham, K., Cheng, L., Hill, A., Killeen, N., Maruff, P., Silbert, B., Brown, B., Sohrabi, H., Savage, G., Vacher, M. (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications, 12(1), Article number 721. https://doi.org/10.1038/s41467-021-21057-y.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2021). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 159(2), 389-402. https://doi.org/10.1111/jnc.15128.

2020

Journal Articles

  • Dhiman, K., Gupta, V., Villemagne, V., Eratne, D., Graham, P., Fowler, C., Bourgeat, P., Li, Q., Collins, S., Bush, A., Rowe, C., Masters, C., Ames, D., Hone, E., Blennow, K., Zetterberg, H., Martins, R. (2020). Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer’s disease. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 12(1), Article number e12005. https://doi.org/10.1002/dad2.12005.
  • Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.

2019

Book Chapters

  • Hone, E., Lim, F., Martins, I. (2019). Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer's Disease. Neurodegeneration and Alzheimer's Disease The role of diabetes, Genetics, Hormones and Lifestyle (189-230). John Wiley & Sons. https://doi.org/10.1002/9781119356752.ch7.

Journal Articles

  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T. (2019). Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(1), 740-750. https://doi.org/10.1016/j.trci.2019.09.015.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A. (2019). A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220. https://doi.org/10.1126/sciadv.aau7220.
  • Mputhia, Z., Hone, E., Tripathi, T., Sargeant, T., Martins, R., Bharadwaj, P. (2019). Autophagy Modulation as a Treatment of Amyloid Diseases. Molecules, 24(18), Article 3372. https://doi.org/10.3390/molecules24183372.

2018

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

2017

Journal Articles

  • Mirzaei, M., Gupta, V., Chick, JM., Greco, TM., Wu, Y., Chitranshi, N., Vander Wall, R., Hone, E., Deng, L., Dheer, Y., Abbasi, M., Rezaeian, M., Braidy, N., You, Y., Hosseini Salekdeh, G., Haynes, PA., Molloy, MP., Martins, R., Cristea, IM., Gygi, SP., Graham, SL., Gupta, VK. (2017). Age-related neurodegenerative disease associated pathways identified in retinal and vitreousproteome from human glaucoma eyes. Scientific Reports, 7(1), Article number 12685. https://doi.org/10.1038/s41598-017-12858-7.
  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057. https://doi.org/10.1038/s41598-017-14020-9.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R. (2017). Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72. https://doi.org/10.1016/j.dadm.2017.04.003.

2016

Journal Articles

  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.

2015

Journal Articles

  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.

2014

Journal Articles

  • Ortiz-Virumbrales, M., Ruiz, M., Hone, E., Dolios, G., Wang, R., Morant, A., Kottwitz, J., Ozelius, LJ., Gandy, S., Ehrlich, M. (2014). Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions. Acta Neuropathologica Communications, 18(2), 139. https://doi.org/10.1186/s40478-014-0139-1.

2010

Journal Articles

  • Sharman, M., Morici, M., Hone, E., Berger, T., Taddei, K., Martins, I., Lim, WL., Singh, S., Wenk, M., Ghiso, J., Buxbaum, JD., Gandy, S., Martins, R. (2010). APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-ß42 in APOE Knock-in and Knock-out Mice. Journal of Alzheimer's Disease, 21(2), 403-409. https://doi.org/10.3233/JAD-2010-100141.

2008

Journal Articles

  • Rodrigues, M., Verdile, G., Foster, J., Hogervorst, E., Joesbury, K., Dhaliwal, S., Corder, E., Laws, S., Hone, E., Prince, R., Devine, A., Mehta, P., Beilby, J., Atwood, C., Martins, R. (2008). Gonadotropins and Cognition in Older Women. Journal of Alzheimer's disease, 13(3), 267-274.

2006

Journal Articles

  • Martins, I., Hone, E., Foster, J., Sunram-Lea, S., Gnjec, A., Fuller, S., Nolan, DA., Gandy, S., Martins, R. (2006). Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry, 11(8), 721-736.

2005

Journal Articles

  • Hone, E., Martins, I., Jeoung, M., Ji, T., Gandy, S., Martins, R. (2005). Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoforms specific receptor binding. Journal of Alzheimer's disease, 7(4), 303-314.

2003

Journal Articles

  • Dean, B., Laws, S., Hone, E., Taddei, K., Scarr, E., Thomas, E., Harper, C., McClean, C., Masters, C., Lautenschlager, N., Gandy, S., Martins, R. (2003). Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry, 54(6), 616-622.
  • Laws, S., Hone, E., Gandy, S., Martins, R. (2003). Expanding the association between the APOE gene and the risk of Alzheimer's disease: possible roles for APOE promoter polymorphisms and alterations in APOE transcription. Journal of Neurochemistry, 84(6), 1215-1236.

Research Projects

  • Analysis of neurofilament biomarkers for Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and childhood dementia, National Foundation for Medical Research and Innovation, Alzheimer's Disease, 2023 ‑ 2025, $250,000.
  • In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease, National Foundation for Medical Research and Innovation, NFMRI - Grant, 2020 ‑ 2024, $170,000.
  • Sponsorship of Research Fellows (multiple roles), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2022 ‑ 2024, $1,480,000.
  • Sponsorship of Research Fellow (multiple roles), Lions Alzheimer's Foundation, Sponsorship, 2022 ‑ 2024, $953,000.
  • In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease (AD), CWEK Pty Ltd, Scholarships to Support Industry Engagement PhD Projects, 2018 ‑ 2023, $32,500.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Sponsorship Agreement Post-Doctoral Research Fellow, Australian Alzheimer's Research Foundation, Neuroscience Research Institute - Sponsorship, 2018 ‑ 2019, $94,922.
  • Targeting chaperone mediated autophagy to alleviate Aβ accumulation and toxicity in AD , Dementia Australia Research Foundation, AADRF - Dementia Grants Program, 2015 ‑ 2016, $50,000.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Doctor of Philosophy, Hyperspectral retinal imaging method for early non-invasive detection of Alzheimer's disease

Associate Supervisor

  • Doctor of Philosophy, Investigation of neurofilament light protein as a diagnostic blood biomarker for Alzheimer's disease, Parkinson's disease, Mulitple sclerosis, and childhood dementia
  • Doctor of Philosophy, Development and Validation of an Ultrasensitive Single Molecule Array Digital Assay for Human Glial Fibrillary Acidic Protein (GFAP)

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Investigation of selected nutraceuticals to protect against mitochondrial dysfunction: Potential therapeutic role in Alzheimer's disease
  • Doctor of Philosophy, In vitro assessment to evaluate the potential effects of polyphenol extracts from sorghum on Alzheimer's disease
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