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    • Dr Prashant Bharadwaj
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    • Dr Prashant Bharadwaj

      Dr Prashant Bharadwaj

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Dr Prashant Bharadwaj

Post Doctoral Fellow

Staff Member Details
Telephone: +61 8 6304 2234
Mobile: 0433 579 575
Email: p.bharadwaj@ecu.edu.au
Campus: Joondalup  
Room: JO17.108  
ORCID iD: https://orcid.org/0000-0003-4361-9906

Prashant is a Post Doctoral Research Fellow in Neuroscience within the School of Medical and Health Sciences.

Background

  • April 2016-present: NHMRC-ARC Dementia Research Development Fellow, Edith Cowan University, WA, Australia
  • April 2016-present: Adjunct Research Fellow, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • April 2015- Mar 2016: Research Associate, School of Biomedical Sciences, CHIRI Biosciences Research Precinct, Curtin University, WA, Australia
  • Dec 2011- present: Postdoctoral Research Fellow, School of Medical Sciences, Edith Cowan University, WA, Australia

Professional Associations

  • 2010-2011: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART)
  • 2009-2010: Australian Society for Medical Research
  • 2007-2008: The Australian Society of Microbiology
  • 2007- present: Australasian Yeast Group:

Awards and Recognition

Other

  • 2008-2011: Full time PhD Scholarship and Tuition Fee Waiver: Centre of Excellence for Alzheimer’s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Faculty of Computing Health Sciences, Edith Cowan University
  • 2009-2011: PhD Top-up Scholarship: CSIRO, Material Science and Engineering, Parkville, Victoria, Preventive Health Flagship
  • 2010: CSIRO Preventive Health Flagship Travel Award (International Conference on Alzheimer’s Disease, Hawaii)

Research Areas and Interests

  • Alzheimer’s disease
  • Beta amyloid protein
  • Autophagy
  • Neuroprotective genes

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2011.
  • Master of Biotechnology, Royal Melbourne Institute of Technology, 2007.
  • Bachelor of Engineering, India, 2004.

Research Outputs

2024

Journal Articles

  • Abdulraheem, R., Martins, R., Bharadwaj, P., Li, Z., Coorey, R., Johnson, S., Fernando, B. (2024). Nutrients and polyphenols-rich Sorghum bicolor genotypes as complementary therapy for Alzheimer’s disease. Phytochemistry Reviews, 2024(Article in press), TBD. https://doi.org/10.1007/s11101-024-09942-y.

2022

Journal Articles

  • Pedrini, S., Chatterjee, P., Nakamura, A., Tegg, M., Hone, E., Rainey-Smith, S., Rowe, C., Dore, V., Villemagne, V., Ames, D., Kaneko, N., Kirby, S., Taddei, K., Fernando, B., Martins, I., Bharadwaj, P., Sohrabi, H., Masters, C., Brown, B., Martins, R. (2022). The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults. Frontiers in Aging Neuroscience, 14(2022), article number 771214. https://doi.org/10.3389/fnagi.2022.771214.
  • Dharmaraj, G., Arigo, F., Young, K., Martins, R., Mancera, R., Bharadwaj, P. (2022). Novel Amylin Analogues Reduce Amyloid-β Cross-Seeding Aggregation and Neurotoxicity. Journal of Alzheimer's Disease, 87(1), 373-390. https://doi.org/10.3233/JAD-215339.

2020

Journal Articles

  • Bharadwaj, P., Martins, R. (2020). Autophagy modulates Aβ accumulation and formation of aggregates in yeast. Molecular and Cellular Neuroscience, 104(April 2020), Article 103466. https://doi.org/10.1016/j.mcn.2020.103466.
  • Jayatunga, P., Hone, E., Bharadwaj, P., Garg, M., Verdile, G., Guillemin, G., Martins, R. (2020). Targeting Mitophagy in Alzheimer's Disease. Journal of Alzheimer's Disease, 78(4), 1273-1297. https://doi.org/10.3233/JAD-191258.
  • Bharadwaj, P., Martins, R. (2020). A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against cell death in yeast. Neural Regeneration Research, 15(10), 1931-1936. https://doi.org/10.4103/1673-5374.280318.
  • Fernando, B., Martins, I., Morici, M., Bharadwaj, P., Rainey-Smith, S., Lim, F., Martins, R. (2020). Sodium butyrate reduces brain amyloid-β levels and improves cognitive memory performance in an Alzheimer's disease transgenic mouse model at an early disease stage. Journal of Alzheimer's Disease, 74(1), 91-99. https://doi.org/10.3233/JAD-190120.
  • Teimouri, E., Rainey-Smith, S., Bharadwaj, P., Verdile, G., Martins, R. (2020). Amla Therapy as a Potential Modulator of Alzheimer’s Disease Risk Factors and Physiological Change. Journal of Alzheimer's Disease, 74(3), 713-733. https://doi.org/10.3233/JAD-191033.
  • Krishnan, S., Shrestha, Y., Jayatunga, P., Rea, S., Martins, R., Bharadwaj, P. (2020). Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease. International Journal of Molecular Sciences, 21(18), Article number 6739. https://doi.org/10.3390/ijms21186739.
  • Bharadwaj, P., Martins, R. (2020). PRKAG2 Gene Expression Is Elevated and its Protein Levels Are Associated with Increased Amyloid-B Accumulation in the Alzheimer’s Disease Brain. Journal of Alzheimer's Disease, 74(2), 441-448. https://doi.org/10.3233/JAD-190948.
  • Bharadwaj, P., Solomon, T., Sahoo, B., Ignasiak, K., Gaskin, S., Rowles, J., Verdile, G., Howard, M., Bond, C., Ramamoorthy, A., Martins, R., Newsholme, P. (2020). Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells. Scientific Reports, 10(1), Article number 10356. https://doi.org/10.1038/s41598-020-66602-9.

2019

Journal Articles

2018

Journal Articles

  • Moore, S., Sonar, K., Bharadwaj, P., Deplazes, E., Mancera, R. (2018). Characterisation of the structure and oligomerisation of islet amyloid polypeptides (IAPP). Molecules, 23(9), article no.2142. https://doi.org/10.3390/molecules23092142.
  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.
  • Bharadwaj, P., Solomon, T., Malajczuk, C., Mancera, R., Howard, M., Arrigan, D., Newsholme, P., Martins, R. (2018). Role of the cell membrane interface in modulating production and uptake of Alzheimer's beta amyloid protein. BBA: Biomembranes, 1860(9), 1639-1651. https://doi.org/10.1016/j.bbamem.2018.03.015.

2017

Journal Articles

  • Bharadwaj, P., Wijesekara, N., Liyanapathirana, M., Newsholme, P., Ittner, L., Fraser, P., Verdile, G. (2017). The Link between Type 2 Diabetes and Neurodegeneration: Roles for Amyloid-B, Amylin, and Tau Proteins. Journal of Alzheimer's Disease, 59(2), 421-432. https://doi.org/10.3233/JAD-161192.

2016

Journal Articles

  • Porter, T., Bharadwaj, P., Groth, D., Paxman, A., Laws, S., Martins, R., Verdile, G. (2016). The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity. Journal of Alzheimer's Disease, 50(3), 895-905. https://doi.org/10.3233/JAD-150790.

2013

Journal Articles

  • Bharadwaj, P., Head, R., Martins, R., Raussens, V., Sarroukh, R., Jegasothy, H., Waddington, L., Bennett, L. (2013). Modulation of amyloid-β 1-42 structure and toxicity by proline-rich whey peptides. Food and Function, 4(1), 92-103. https://doi.org/10.1039/c2fo30111c.
  • Steele, JW., Ju, S., Lachenmayer, M., Liken, J., Stock, A., Kim, SH., Delgado, L., Alfaro, I., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Protter, A., Martins, R., Ehrlich, M., Yue, Z., Petsko, G., Gandy, S. (2013). Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry, 18(8), 882-888. https://doi.org/10.1038/mp.2012.115.
  • Steele, JW., Lachenmayer, ML., Ju, S., Stock, A., Liken, J., Kim, SH., Delgado, LM., Alfaro, IE., Bernales, S., Verdile, G., Bharadwaj, P., Gupta, V., Barr, R., Friss, A., Dolios, G., Wang, R., Ringe, D., Fraser, P., Westaway, D., St George-Hyslop, P0., Szabo, P., Relkin, N0., Buxbaum, J0., Glabe, C0., Protter, A0., Martins, R., Ehrlich, M0., Petsko, G0. (2013). Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry, 18(8), 889-897. https://doi.org/10.1038/mp.2012.106.
  • Bharadwaj, P., Bates, K., Porter, T., Teimouri, E., Perry, G., Steele, JW., Gandy, S., Groth, D., Martins, R., Verdile, G. (2013). Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer’s and other neurodegenerative diseases. Translational Psychiatry, 3(2013), Article no. e332. https://doi.org/10.1038/tp.2013.97.

2012

Journal Articles

  • Bharadwaj, P., Verdile, G., Barr, R., Gupta, V., Steele, J., Lachenmayer, L., Yue, Z., Ehrlich, M., Petsko, G., Ju, S., Ringe, D., Sankovich, S., Caine, J., Macreadie, I., Gandy, S., Martins, R. (2012). Latrepirdine (Dimebon™) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's disease, 32(4), 949-967. https://doi.org/10.3233/JAD-2012-120178.

2011

Journal Articles

  • Caine, JM., Bharadwaj, P., Sankovich, SE., Ciccotosto, GD., Streltsov, VA., Varghese, J. (2011). Oligomerization and toxicity of Aβ fusion proteins. Biochemical and Biophysical Research Communications, 409(3), 477-482. https://doi.org/10.1016/j.bbrc.2011.05.029.

Research Projects

  • Exploring genetic biomarkers associated with neurodegeneration in childhood dementia, Department of Health WA, FHRIF Research Excellence Awards 2022, 2022 ‑ 2025, $160,000.
  • Prognostic biomarkers for childhood dementia, Department of Health WA, WA Child Research Fund, 2021 ‑ 2025, $249,967.
  • Analysis of neurofilament biomarkers for Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and childhood dementia, National Foundation for Medical Research and Innovation, Alzheimer's Disease, 2023 ‑ 2025, $250,000.
  • Sponsorship of Research Fellows (multiple roles), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2022 ‑ 2024, $1,480,000.
  • Neuroprotective functions of autophagy regulators in Alzheimer's disease, National Health and Medical Research Council, Dementia Research Development Fellowship, 2016 ‑ 2022, $640,220.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Targeting chaperone mediated autophagy to alleviate Aβ accumulation and toxicity in AD , Dementia Australia Research Foundation, AADRF - Dementia Grants Program, 2015 ‑ 2016, $50,000.
  • Short chain fatty acids are a useful therapy for the treatment of Alzheimer's Disease. , Hollywood Private Hospital Research Foundation, Grant, 2013 ‑ 2016, $20,000.
  • Effects of Latrepirdine on beta amyloid clearance, aggregation and neurodegeneration in Alzheimer’s disease, Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2014 ‑ 2015, $12,555.
  • Protective role of autophagy genes in Alzheimer’s disease, Edith Cowan University, ECU Early Career Researcher Grant - 2014, 2014, $10,000.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Doctor of Philosophy, Small molecule proteostasis enhancers for Alzheimer's Disease (AD)
  • Doctor of Philosophy, Investigation of neurofilament light protein as a diagnostic blood biomarker for Alzheimer's disease, Parkinson's disease, Mulitple sclerosis, and childhood dementia

Associate Supervisor

  • Doctor of Philosophy, In vivo Analysis of Sorghum Polyphenols in Alzheimer's Disease Worm Models
  • Doctor of Philosophy, Assessing neuroprotective effects of short chain fatty acids and medium chain fatty acids in Alzheimer's disease

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Investigation of the role of amla in modulating cholesterol metabolism, and understanding its mechanism of action in reducing alzheimer's risk
  • Master of Medical and Health Science by Research, Developing and optimizing methods for grape seed polyphenol extraction
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