Top of page

Student/Staff Portal
Global Site Navigation

School of Medical and Health Sciences

Local Section Navigation
You are here: Main Content
  • Dr Tenielle Porter

    Dr Tenielle Porter

Related Contents

  • See Also
  • Google Scholar profile
    https://scholar.google.com.au/citations?user=zJKdosMAAAAJ&hl=en
  • Google Scholar profile
  • ResearchGate profile
    https://www.researchgate.net/profile/Tenielle_Porter
  • ResearchGate profile
  • LinkedIn profile
    https://www.linkedin.com/in/tenielle-porter-a287aba0/
  • LinkedIn profile

Dr Tenielle Porter

Lecturer

Staff Member Details
Telephone: +61 8 6304 5685
Email: t.porter@ecu.edu.au
Campus: Joondalup  
Room: JO21.508  
ORCID iD: https://orcid.org/0000-0002-7887-6622

Dr Tenielle Porter is a Strategic Research Fellow in the School of Medical and Health Sciences and leads the Neurogenetics research group in the Centre for Precision Health, an ECU Strategic Research Centre. Tenielle’s research focuses on understanding the relationship between genetics, lifestyle and markers of Alzheimer’s disease. Specifically, she aims to identify genetic and epigenetic patterns predicting cognitive decline and brain changes during the development of Alzheimer’s disease, and how these relationships are influenced by a person’s lifestyle.

Current Teaching

  • SCH2235 Applied Microbiology
  • MMS2102 Medical Microbiology

Professional Associations

  • 2012 – Present: Australian Society for Medical Research (ASMR)
  • 2014 – Present: Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) - including membership of the Alliance of Women Alzheimer's Researchers (AWARE) and Biofluid Based Biomarkers Professional Interest Areas (PIA)

Awards and Recognition

  • 2019: BioinfoSummer MATHS Award ($4,000)
  • 2019: ECR Collaboration Scheme, Dementia Centre for Research Collaboration ($5,000)
  • 2016: Cooperative Research Centre Association Showcasing Early Career Researchers Finalist ($1,000)
  • 2016: ECU Joondalup 3 Minute Thesis Finalist

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2018.

Research Outputs

2025

Journal Articles

  • Milligan Armstrong, A., O'Brien, E., Porter, T., Dore, V., Bourgeat, P., Maruff, P., Rowe, C., Villemagne, V., Rainey-Smith, S., Laws, S. (2025). Exploring the relationship between melanopsin gene variants, sleep, and markers of brain health. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 17(1), Article number e70056. https://doi.org/https://doi.org/10.1002/dad2.70056.
  • Bhalala, O., Beamish, J., Eratne, D., Summerell, P., Porter, T., Laws, S., Kang, M., Huq, A., Chiu, W., Cadwallader, C., Walterfang, M., Farrand, S., Evans, A., Kelso, W., Churilov, L., Watson, R., Yassi, N., Velakoulis, D., Loi, S. (2025). Blood biomarker profiles in young-onset neurocognitive disorders: A cohort study. Australian and New Zealand Journal of Psychiatry, 2025(Article in press), 11 pages. https://doi.org/https://doi.org/10.1177/00048674241312805.

2024

Journal Articles

  • Jiang, Y., Qu, M., Jiang, M., Jiang, X., Fernandez, S., Porter, T., Laws, S., Masters, C., Guo, H., Cheng, S., Wang, C. (2024). MethylGenotyper: Accurate estimation of SNP Genotypes and Genetic Relatedness from DNA Methylation data. Genomics Proteomics and Bioinformatics, 22(3), Article number qzae044. https://doi.org/10.1093/gpbjnl/qzae044.
  • Marston, K., De Frutos-Lucas, J., Porter, T., Milicic, L., Vacher, M., Sewell, K., Peiffer, J., Laws, S., Brown, B. (2024). Exploration of Alzheimer's disease-related gene expression following high-intensity and moderate-intensity exercise interventions. Journal of Science and Medicine in Sport, 27(12), 828-833. https://doi.org/10.1016/j.jsams.2024.07.017.
  • Nho, K., Risacher, S., Apostolova, L., Bice, P., Brosch, J., Deardorff, R., Faber, K., Farlow, M., Foroud, T., Gao, S., Rosewood, T., Kim, J., Nudelman, K., Yu, M., Aisen, P., Sperling, R., Hooli, B., Shcherbinin, S., Svaldi, D., Jack, C., Jagust, W., Landau, S., Vasanthakumar, A., Waring, J., Dore, V., Laws, S., Masters, C., Porter, T., Rowe, C., Villemagne, V., Dumitrescu, L., Hohman, T., Libby, J., Mormino, E., Buckley, R., Johnson, K., Yang, H., Petersen, R., Ramanan, V., Ertekin-Taner, N., Vemuri, P., Cohen, A., Fan, K., Kamboh, M., Lopez, O., Bennett, D., Ali, M., Benzinger, T., Cruchaga, C., Hobbs, D., De Jager, P., Fujita, M., Jadhav, V., Lamb, B., Tsai, A., Castanho, I., Mill, J., Weiner, M., Saykin, AJ. (2024). CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET. Nature Communications, 15(1), Article number 8251. https://doi.org/10.1038/s41467-024-52298-2.
  • Grammenou, M., Kendall, K., Wilson, C., Porter, T., Laws, S., Haff, G. (2024). Effect of Fitness Level on Time Course of Recovery After Acute Strength and High-Intensity Interval Training. Journal of Strength and Conditioning Research, 38(12), 2055-2064. https://doi.org/10.1519/JSC.0000000000004924.
  • Adewuyi, E., Porter, T., O'Brien, E., Olaniru, O., Verdile, G., Laws, S. (2024). Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders. Communications Biology, 7(1), Article number 643. https://doi.org/10.1038/s42003-024-06333-z.
  • Kirby, A., Porter, T., Adewuyi, E., Laws, S. (2024). Investigating Genetic Overlap between Alzheimer’s Disease, Lipids, and Coronary Artery Disease: A Large-Scale Genome-Wide Cross Trait Analysis. International Journal of Molecular Sciences, 25(16), Article number 8814. https://doi.org/10.3390/ijms25168814.

Conference Publications

  • Fox-Harding, C., Kendall, K., Porter, T., Belladonna, B., Beatty, S., Wallace, R. (2024). A taste of research: Preliminary insights from an undergraduate research training cadetship project in a Western Australian University offering experiences outside the classroom. Proceedings of the 10th International Conference on Higher Education Advances (714-723). Higher Education Advances (HEAd). https://doi.org/10.4995/HEAD24.2024.17153.

2023

Journal Articles

  • Mehramiz, M., Porter, T., O'Brien, E., Rainey-Smith, S., Laws, S. (2023). A Potential Role for Sirtuin-1 in Alzheimer's Disease: Reviewing the Biological and Environmental Evidence. Journal of Alzheimer's Disease Reports, 7(1), 823-843. https://doi.org/10.3233/ADR-220088.
  • Schäfer Hackenhaar, F., Josefsson, M., Nordin Adolfsson, A., Landfors, M., Kauppi, K., Porter, T., Milicic, L., Laws, S., Hultdin, M., Adolfsson, R., Degerman, S., Pudas, S. (2023). Sixteen-Year Longitudinal Evaluation of Blood-Based DNA Methylation Biomarkers for Early Prediction of Alzheimer's Disease. Journal of Alzheimer's Disease, 94(4), 1443-1464. https://doi.org/10.3233/JAD-230039.
  • Milicic, L., Porter, T., Vacher, M., Laws, S. (2023). Utility of DNA Methylation as a Biomarker in Ageing and Alzheimer’s Disease. Journal of Alzheimer's Disease Reports, 7(1), 475-503. https://doi.org/10.3233/ADR-220109.
  • Roberts, B., Laffoon, S., Roberts, A., Porter, T., Fowler, C., Masters, C., Dratz, E., Laws, S. (2023). Discovery of a Missense Mutation (Q222K) of the APOE Gene from the Australian Imaging, Biomarker and Lifestyle Study. Journal of Alzheimer's Disease Reports, 7(1), 165-172. https://doi.org/10.3233/ADR-220075.

2022

Journal Articles

  • Adewuyi, E., O'Brien, E., Nyholt, D., Porter, T., Laws, S. (2022). A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders. Communications Biology, 5(1), article number 691. https://doi.org/10.1038/s42003-022-03607-2.
  • Woodfield, A., Porter, T., Gilani, I., Noordin, S., Li, Q., Collins, S., Martins, R., Maruff, P., Masters, C., Rowe, C., Villemagne, V., Dore, V., Newsholme, P., Laws, S., Verdile, G. (2022). Insulin resistance, cognition and Alzheimer’s disease biomarkers: Evidence that CSF Aβ42 moderates the association between insulin resistance and increased CSF tau levels. Neurobiology of Aging, 114(June 2022), 38-48. https://doi.org/10.1016/j.neurobiolaging.2022.03.004.
  • Milicic, L., Vacher, M., Porter, T., Dore, V., Burnham, S., Bourgeat, P., Shishegar, R., Doecke, J., Armstrong, N., Tankard, R., Maruff, P., Masters, C., Rowe, C., Villemagne, V., Laws, S. (2022). Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume. GeroScience, 44(3), 1807-1823. https://doi.org/10.1007/s11357-022-00558-8.
  • Porter, T., Sim, M., Prince, R., Schousboe, JT., Bondonno, C., Lim, WH., Zhu, K., Kiel, DP., Hodgson, J., Laws, S., Lewis, J. (2022). Abdominal aortic calcification on lateral spine images captured during bone density testing and late-life dementia risk in older women: a prospective cohort study. The Lancet Regional Health - Western Pacific, 26(2022), article number 100502. https://doi.org/10.1016/j.lanwpc.2022.100502.
  • Mehramiz, M., Porter, T., Laws, S., Rainey-Smith, S. (2022). Sleep, Sirtuin 1 and Alzheimer’s disease: a review. Ageing Brain, 2(2022), article number 100050. https://doi.org/10.1016/j.nbas.2022.100050.
  • Jiang, Y., Zhou, X., Wong, H., Ouyang, L., Ip, F., Chau, V., Lau, S., Wu, W., Wong, D., Seo, H., Fu, W., Lai, N., Chen, Y., Chen, Y., Tong, E., Mok, V., Kwok, T., Mok, K., Shaoi, M., Lehallier, B., Losada, P., O'Brien, E., Porter, T., Laws, S., Hardy, J., Wyss-Coray, T., Masters, C., Fu, A., Ip, N. (2022). An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature Aging, 2(7), 616-634. https://doi.org/10.1038/s43587-022-00241-9.
  • Adewuyi, E., O'Brien, E., Porter, T., Laws, S. (2022). Relationship of Cognition and Alzheimer’s Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis. International Journal of Molecular Sciences, 23(24), Article number 16199. https://doi.org/https://doi.org/10.3390/ijms232416199.
  • Vacher, M., Dore, V., Porter, T., Milicic, L., Villemagne, V., Bourgeat, P., Burnham, S., Cox, T., Masters, C., Rowe, C., Fripp, J., Doecke, J., Laws, S. (2022). Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease. BMC Genomics, 23(1), Article 401. https://doi.org/10.1186/s12864-022-08617-2.
  • Cadby, G., Giles, C., Melton, P., Huynh, K., Mellett, N., Duong, T., Nguyen, A., Cinel, M., Smith, A., Olshansky, G., Wang, T., Brozynska, M., Inouye, M., McCarthy, N., Ariff, A., Hung, J., Hui, J., Beilby, J., Dube, M., Watts, G., Shah, S., Wray, N., Lim, F., Chatterjee, P., Martins, I., Laws, S., Porter, T., Vacher, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Taddei, K., Arnold, M., Kastenmuller, G., Nho, K., Saykin, A., Han, X., Kaddurah-Daouk, R., Martins, R., Blangero, J., Meikle, P., Moses, E. (2022). Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease. Nature Communications, 13(1), Article number 3124. https://doi.org/10.1038/s41467-022-30875-7.
  • Brown, B., De Frutos Lucas, J., Porter, T., Frost, N., Vacher, M., Peiffer, J., Laws, S. (2022). A new paradigm for the treatment of Alzheimer's disease: targeting vascular activation. Journal of Alzheimer's Disease, 40(3), 619-630. https://doi.org/10.3233/JAD-220114.
  • Krishnadas, N., Dore, V., Laws, S., Porter, T., Bozinovski, S., Villemagne, V., Rowe, C. (2022). Exploring discordant low amyloid-beta and high neocortical tau PET cases. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), article number e12326. https://doi.org/10.1002/dad2.12326.
  • Vacher, M., Porter, T., Milicic, L., Bourgeat, P., Dore, V., Villemagne, V., Laws, S., Doecke, J. (2022). A Targeted Association Study of Blood-Brain Barrier Gene SNPs and Brain Atrophy. Journal of Alzheimer's Disease, 86(4), 1817-1829. https://doi.org/10.3233/JAD-210644.
  • Woodfield, A., Gonzales, T., Helmerhorst, E., Laws, S., Newsholme, P., Porter, T., Verdile, G. (2022). Current Insights on the Use of Insulin and the Potential Use of Insulin Mimetics in Targeting Insulin Signalling in Alzheimer's Disease. International Journal of Molecular Sciences, 23(24), Article number 15811. https://doi.org/10.3390/ijms232415811.

2021

Journal Articles

  • Fowler, C., Rainey-Smith, S., Bird, S., Bomke, J., Bourgeat, P., Brown, B., Burnham, S., Bush, A., Chadunow, C., Collins, S., Doecke, J., Dore, V., Ellis, K., Evered, L., Fazlollahi, A., Fripp, J., Kirby, S., Gibson, S., Grenfell, R., Harrison, E., Head, R., Jin, L., Kamer, A., Lamb, F., Lautenschlager, N., Laws, S., Li, Q., Lim, L., Lim, Yy., Louey, A., Macaulay, L., Mackintosh, L., Martins, R., Maruff, P., Masters, C., McBride, S., Milicic, L., Peretti, M., Pertile, K., Porter, T., Radler, M., Rembach, A., Robertson, J., Rodriguez, M., Rowe, C., Rumble, R., Salvado, O., Savage, G., Silbert, B., Soh, M., Sohrabi, H., Taddei, K., Taddei, T., Thai, C., Trounson, B., Tyrell, R., Vacher, M., Varghese, S., Villemagne, V., Weinborn, M., Woodward, M., Xia, Y., Ames, D. (2021). Fifteen years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and observations from 2,359 older adults spanning the spectrum from cognitive normality to Alzheimer's disease. Journal of Alzheimer's Disease Reports, 5(1), 443-468. https://doi.org/10.3233/ADR-210005.
  • Belloy, M., Eger, S., Le Guen, Y., Napolioni, V., Deters, K., Yang, H., Scelsi, M., Porter, T., James, S., Wong, A., Schott, J., Sperling, R., Laws, S., Mormino, E., He, Z., Han, S., Altmann, A., Greicius, M. (2021). KL*VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE*4 carriers. Neurobiology of Aging, 101(May 2021), 123-129. https://doi.org/10.1016/j.neurobiolaging.2021.01.008.
  • Milligan Armstrong, A., Porter, T., Quek, H., White, A., Haynes, J., Jackaman, C., Villemagne, V., Munyard, K., Laws, S., Verdile, G., Groth, D. (2021). Chronic stress and Alzheimer's disease: the interplay between the hypothalamic-pituitary-adrenal axis, genetics and microglia. Biological Reviews, 96(5), 2209-2228. https://doi.org/10.1111/brv.12750.
  • Tan, S., Porter, T., Bucks, R., Weinborn, M., Milicic, L., Brown, A., Rainey-Smith, S., Taddei, K., Ames, D., Masters, C., Maruff, P., Savage, G., Rowe, C., Villemagne, V., Brown, B., Sohrabi, H., Laws, S., Martins, R. (2021). Androgen receptor CAG repeat length as a moderator of the relationship between free testosterone levels and cognition. Hormones and Behaviour, 131(May 2021), Article number 104966. https://doi.org/10.1016/j.yhbeh.2021.104966.
  • Cruickshank, T., Porter, T., Laws, S., Ziman, M., Bartlett, D. (2021). Hair and salivary cortisol and their relationship with lifestyle, mood and cognitive outcomes in premanifest Huntington’s disease. Scientific Reports, 11(December 2021), Article number 5464. https://doi.org/10.1038/s41598-021-84726-4.
  • Fernandez, S., Burnham, S., Milicic, L., Savage, G., Maruff, P., Peretti, M., Sohrabi, H., Lam, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Porter, T., Laws, S. (2021). SPON1 Is Associated with Amyloid-β and APOE ε4-Related Cognitive Decline in Cognitively Normal Adults. Journal of Alzheimer's Disease Reports, 5(1), 111-120. https://doi.org/10.3233/ADR-200246.
  • Moussavi Nik, S., Porter, T., Newman, M., Bartlett, B., Khan, I., Sabale, M., Eccles, M., Woodfield, A., Groth, D., Dore, V., Villemagne, V., Masters, C., Martins, R., Laws, S., Lardelli, M., Verdile, G. (2021). Relevance of a truncated PRESENILIN 2 Transcript to Alzheimer's disease and neurodegeneration. Journal of Alzheimer's Disease, 80(4), 1479-1489. https://doi.org/10.3233/jad-201133.

2020

Journal Articles

  • Zhang, Q., Sidorenko, J., Couvy-Duchesne, B., Marioni, R., Wright, M., Goate, A., Marcora, E., Huang, K., Porter, T., Laws, S., Sachdev, P., Mather, K., Armstrong, N., Thalamuthu, A., Brodaty, H., Yengo, L., Yang, J., Wray, N., McRae, A., Visscher, P. (2020). Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture. Nature Communications, 11(1), Article number 4799. https://doi.org/10.1038/s41467-020-18534-1.
  • Burnham, S., Laws, S., Budgeon, C., Dore, V., Porter, T., Bourgeat, P., Buckley, R., Murray, K., Ellis, K., Turlach, B., Salvado, O., Ames, D., Martins, R., Rentz, D., Masters, C., Rowe, C., Villemagne, V. (2020). Impact of APOE-ε4 carriage on the onset and rates of neocortical Aβ-amyloid deposition. Neurobiology of Aging, 95(November 2020), 46-55. https://doi.org/10.1016/j.neurobiolaging.2020.06.001.

2019

Journal Articles

  • Vacher, M., Porter, T., Villemagne, V., Milicic, L., Peretti, M., Fowler, C., Martins, R., Rainey-Smith, S., Ames, D., Masters, C., Rowe, C., Doecke, J., Laws, S. (2019). Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition. Scientific Reports, 9(2019), Article number 17069. https://doi.org/10.1038/s41598-019-53604-5.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Sohrabi, H., Peretti, M., Lim, YY., Weinborn, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults. IBRO Reports, 6(June 2019), 147-152. https://doi.org/10.1016/j.ibror.2019.05.001.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2019). Klotho allele status is not associated with Ab and APOE ε4erelated cognitive decline in preclinical Alzheimer’s disease. Neurobiology of Aging, 76(April 2019), 162-165. https://doi.org/10.1016/j.neurobiolaging.2018.12.014.

2018

Journal Articles

  • Porter, T., Burnham, S., Savage, G., Lim, YY., Maruff, P., Milicic, L., Peretti, M., Ames, D., Masters, C., Martins, R., Rainey-Smith, S., Rowe, C., Salvado, O., Taddei, K., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). A polygenic risk score derived from episodic memory weighted genetic variants is associated with cognitive decline in preclinical Alzheimer's disease. Frontiers in Aging Neuroscience, 10(Dec 2018), Article number 423. https://doi.org/10.3389/fnagi.2018.00423.
  • Porter, T., Burnham, S., Dore, V., Savage, G., Bourgeat, P., Begemann, K., Milicic, L., Ames, D., Bush, A., Maruff, P., Masters, C., Rowe, C., Rainey-Smith, S., Martins, R., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4- positive cognitively normal adults with high Aβ-amyloid burden. Scientific Reports, 8(1), Article no.2034. https://doi.org/10.1038/s41598-018-20513-y.
  • Porter, T., Burnham, S., Milicic, L., Savage, G., Maruff, P., Lim, YY., Li, Q., Ames, D., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Groth, D., Verdile, G., Villemagne, V., Laws, S. (2018). Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study. Journal of Alzheimer's Disease, 66(3), 1193-1211. https://doi.org/10.3233/JAD-180713.
  • Porter, T., Villemagne, V., Savage, G., Milicic, L., Lim, YY., Maruff, P., Masters, C., Ames, D., Bush, A., Martins, R., Rainey-Smith, S., Rowe, C., Taddei, K., Groth, D., Verdile, G., Burnham, S., Laws, S. (2018). Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease. Personalized Medicine in Psychiatry, 7-8(2018), 14-20. https://doi.org/10.1016/j.pmip.2018.03.001.
  • Rainey-Smith, S., Mazzucchelli, G., Villemagne, V., Brown, B., Porter, T., Weinborn, M., Bucks, R., Milicic, L., Sohrabi, H., Taddei, K., Ames, D., Maruff, P., Masters, C., Rowe, C., Salvado, O., Martins, R., Laws, S. (2018). Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. Translational Psychiatry, 8(1), Article no. 47. https://doi.org/10.1038/s41398-018-0094-x.

2017

Journal Articles

  • Laws, S., Gaskin, S., Woodfield, A., Srikanth, V., Bruce, D., Fraser, P., Porter, T., Newsholme, P., Wijesekara, N., Burnham, S., Dore, V., Li, Q., Maruff, P., Masters, C., Rainey-Smith, S., Rowe, C., Salvado, O., Villemagne, V., Martins, R., Verdile, G. (2017). Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults. Scientific Reports, 7(1), Article no. 9766. https://doi.org/10.1038/s41598-017-09577-4.
  • Pietrzak, RH., Laws, S., Lim, YY., Bender, SJ., Porter, T., Doecke, J., Ames, DJ., Fowler, CJ., Masters, CL., Milicic, L., Rainey-Smith, S., Villemagne, VL., Rowe, CC., Martins, R., Maruff, P. (2017). Plasma Cortisol,Brain Amyloid-β, and Cognitive Decline in Preclinical Alzheimer’s Disease: A 6-Year Prospective Cohort Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(1), 45-52. https://doi.org/10.1016/j.bpsc.2016.08.006.
  • Hollands, S., Lim, YY., Laws, S., Villemagne, V., Pietrzak, R., Harrington, K., Porter, T., Snyder, P., Ames, D., Fowler, C., Rainey-Smith, S., Martins, R., Salvado, O., Robertson, J., Rowe, C., Masters, C., Maruff, P. (2017). APOE e4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults. Journal of Alzheimer's Disease, 57(2), 411-422. https://doi.org/10.3233/JAD-161019.
  • Lim, YY., Rainey-Smith, S., Lim, Y., Laws, S., Gupta, V., Porter, T., Bourgeat, P., Ames, D., Fowler, C., Salvado, O., Villemagne, V., Rowe, C., Masters, C., Zhou, XF., Martins, R., Maruff, P. (2017). BDNF Val66Met in preclinical Alzheimer’s disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF. International Psychogeriatrics, 29(11), 1825-1834. https://doi.org/10.1017/S1041610217001284.

Research Projects

  • Validate ARIA Risk genes using brain MRI/PET imaging endpoints, Lilly, Lilly Research Award Program, 2024 ‑ 2026, $453,645.
  • The interaction of genetic and lifestyle factors affecting progression in neurodegenerative disorders, Department of Health WA, Near Miss Merit Awards, 2021 ‑ 2023, $74,000.
  • Defining genetic, epigenetic and transcriptomic profiles of progression in preclinical Alzheimer’s disease, Department of Health WA, Near Miss Merit Awards, 2020 ‑ 2022, $95,000.
  • Understanding the biology behind the benefits of physical activity in the elderly., Edith Cowan University, ECU Early Career Researcher Grant – 2020, 2020 ‑ 2021, $26,920.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Master of Medical and Health Science by Research, Investigating relationships between genetic variation in a metabolic clearance pathway, physical activity, and Alzheimer's Disease
  • Master of Medical and Health Science by Research, Investigating the genetic relationship between Alzheimer's disease and physical activity.

Co-principal Supervisor

  • Doctor of Philosophy, Unveiling genomic signature of metabolic and inflammatory biomarkers in Alzheimer's disease
  • Doctor of Philosophy, Assessing the genetic relationship between Alzheimer's disease and inflammatory and autoimmune-related traits to identify potential drug targets.

Associate Supervisor

  • Doctor of Philosophy, Genetic Variation in Exercise Response: Implications for Physical Characteristics, Recovery Dynamics and Training Adaptations.

Completed Supervisions

Principal Supervisor

  • Doctor of Philosophy, A multi-method approach to exploring the role of genetics in explaining cognitive decline heterogeneity across the Alzheimer's disease spectrum

Associate Supervisor

  • Doctor of Philosophy, Peripheral DNA methylation patterns, methylation age and Alzheimer's disease risk and related phenotypes
  • Doctor of Philosophy, The impact of the interaction between SIRT1 and lifestyle factors on Alzheimer’s disease risk and related phenotypes
  • Master of Science (Medical Science), Dna methylation of the clusterin promoter: Associations with alzheimer's disease risk and related phenotypes
Skip to top of page