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Mr Steve Pedrini

Research Associate

Staff Member Details
Email: s.pedrini@ecu.edu.au
Campus: Joondalup  
ORCID iD: https://orcid.org/0000-0002-6409-8022

Steve is currently involved in projects involving biomarkers in Alzheimer’s Disease.

Research Areas and Interests

  • Alzheimer, Dementia, Biomarkers

Qualifications

  • Doctor of Philosophy, Edith Cowan University, 2023.
  • Master of Science in Biology, Italy, 1997.

Research Outputs

2024

Journal Articles

  • Sewell, KR., Rainey-Smith, S., Pedrini, S., Peiffer, JJ., Sohrabi, H., Taddei, K., Markovic, SJ., Martins, R., Brown, B. (2024). The impact of exercise on blood-based biomarkers of Alzheimer’s disease in cognitively unimpaired older adults. GeroScience, 2024(Article in press), TBD. https://doi.org/10.1007/s11357-024-01130-2.
  • Savar, SM., Ma, B., Hone, E., Jahan, F., Markovic, S., Pedrini, S., Shemehsavar, S., Easwaran, V., Taddei, K., Gardener, S., Chhatwal, JP., Van Etten, ES., Van Osch, MJ., Clarke, D., Gnjec, A., Van Buchem, MA., Wermer, MJ., Hankey, GJ., Greenberg, SM., Martins, R., Sohrabi, H. (2024). Fluid biomarkers in cerebral amyloid angiopathy. Frontiers in Neuroscience, 18(2024), article number 1347320. https://doi.org/10.3389/fnins.2024.1347320.

2023

Journal Articles

  • Chatterjee, P., Pedrini, S., Doecke, J., Thota, R., Villemagne, V., Doré, V., Singh, A., Wang, P., Rainey-Smith, S., Fowler, C., Taddei, K., Sohrabi, H., Molloy, M., Ames, D., Maruff, P., Rowe, C., Masters, C., Martins, R. (2023). Plasma Aβ42/40 ratio, p-tau181, GFAP, and NfL across the Alzheimer's disease continuum: A cross-sectional and longitudinal study in the AIBL cohort. Alzheimer's and Dementia, 19(4), 1117-1134. https://doi.org/10.1002/alz.12724.
  • Chatterjee, P., Dore, V., Pedrini, S., Krishnadas, N., Thota, R., Bourgeat, P., Ikonomovic, MD., Rainey-Smith, S., Burnham, SC., Fowler, C., Taddei, K., Mulligan, R., Ames, D., Masters, CL., Fripp, J., Rowe, CC., Martins, R., Villemagne, VL. (2023). Plasma Glial Fibrillary Acidic Protein Is Associated With 18F-Smbt-1 Pet: Two Putative Astrocyte Reactivity Biomarkers For Alzheimer'S Disease. Journal of Alzheimer's Disease, 92(2), 615-628. https://doi.org/10.3233/JAD-220908.
  • Chatterjee, P., Vermunt, L., Gordon, B., Pedrini, S., Boonkamp, L., Armstrong, N., Xiong, C., Singh, A., Li, Y., Sohrabi, H., Taddei, K., Molloy, M., Benzinger, T., Morris, J., Karch, C., Berman, S., Chhatwal, J., Cruchaga, C., Graff-Radford, N., Day, G., Farlow, M., Fox, N., Goate, A., Hassenstab, J., Lee, J., Levin, J., McDade, E., Mori, H., Perrin, R., Sanchez-Valle, R., Schofield, P., Levey, A., Jucker, M., Masters, C., Fagan, A., Bateman, R., Martins, R., Teunissen, C. (2023). Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's and Dementia, 19(7), 2790-2804. https://doi.org/10.1002/alz.12879.
  • Yuan, J., Pedrini, S., Thota, R., Doecke, J., Chatterjee, P., Sohrabi, H., Teunissen, CE., Verberk, IM., Stoops, E., Vanderstichele, H., Meloni, BP., Mitchell, C., Rainey-Smith, S., Goozee, K., Tai, AC., Ashton, N., Zetterberg, H., Blennow, K., Gao, J., Liu, D., Mastaglia, F., Inderjeeth, C., Zheng, M., Martins, R. (2023). Elevated Plasma Sclerostin Is Associated With High Brain Amyloid-Β Load In Cognitively Normal Older Adults. Npj Aging, 9(1), article number 17. https://doi.org/10.1038/s41514-023-00114-4.

2022

Journal Articles

  • Pedrini, S., Doecke, J., Hone, E., Wang, P., Thota, R., Bush, A., Rowe, C., Dore, V., Villemagne, V., Ames, D., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Taddei, K., Gandy, S., Masters, C., Chatterjee, P., Martins, R. (2022). Plasma high-density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume. Journal of Neurochemistry, 163(1), 53-67. https://doi.org/10.1111/jnc.15681.
  • Pedrini, S., Chatterjee, P., Nakamura, A., Tegg, M., Hone, E., Rainey-Smith, S., Rowe, C., Dore, V., Villemagne, V., Ames, D., Kaneko, N., Kirby, S., Taddei, K., Fernando, B., Martins, I., Bharadwaj, P., Sohrabi, H., Masters, C., Brown, B., Martins, R. (2022). The Association Between Alzheimer's Disease-Related Markers and Physical Activity in Cognitively Normal Older Adults. Frontiers in Aging Neuroscience, 14(2022), article number 771214. https://doi.org/10.3389/fnagi.2022.771214.
  • Thota, R., Chatterjee, P., Pedrini, S., Hone, E., Ferguson, J., Garg, M., Martins, R. (2022). Association of Plasma Neurofilament Light Chain With Glycaemic Control and Insulin Resistance in Middle-Aged Adults. Frontiers in Endocrinology, 13(2022), article number 915449. https://doi.org/10.3389/fendo.2022.915449.
  • Chatterjee, P., Pedrini, S., Ashton, N., Tegg, M., Goozee, K., Singh, A., Karikari, T., Simrén, J., Vanmechelen, E., Armstrong, N., Hone, E., Asih, P., Taddei, K., Doré, V., Villemagne, V., Sohrabi, H., Zetterberg, H., Masters, C., Blennow, K., Martins, R. (2022). Diagnostic and prognostic plasma biomarkers for preclinical Alzheimer's disease. Alzheimer's and Dementia, 18(6), 1141-1154. https://doi.org/10.1002/alz.12447.

2021

Journal Articles

  • Pedrini, S., Chatterjee, P., Hone, E., Martins, R. (2021). High-density lipoprotein-related cholesterol metabolism in Alzheimer’s disease. Journal of Neurochemistry, 159(2), 343-377. https://doi.org/10.1111/jnc.15170.
  • Chatterjee, P., Cheong, Y., Bhatnagar, A., Goozee, K., Wu, Y., McKay, M., Martins, I., Lim, F., Pedrini, S., Tegg, M., Villemagne, V., Asih, P., Dave, P., Shah, T., Dias, C., Fuller, S., Hillebrandt, H., Gupta, S., Hone, E., Taddei, K., Zetterberg, H., Blennow, K., Sohrabi, H., Martins, R. (2021). Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults. Journal of Neurochemistry, 159(2), 389-402. https://doi.org/10.1111/jnc.15128.
  • Chatterjee, P., Pedrini, S., Stoops, E., Goozee, K., Villemagne, V., Asih, P., Verberk, I., Dave, P., Taddei, K., Sohrabi, H., Zetterberg, H., Blennow, K., Teunissen, C., Vanderstichele, H., Martins, R. (2021). Plasma glial fibrillary acidic protein is elevated in cognitively normal older adults at risk of Alzheimer’s disease. Translational Psychiatry, 11(June 2021), Article number 27. https://doi.org/10.1038/s41398-020-01137-1.
  • Chatterjee, P., Tegg, M., Pedrini, S., Fagan, A., Xiong, C., Singh, A., Taddei, K., Gardener, S., Masters, C., Schofield, P., Multhaup, G., Benzinger, T., Morris, J., Bateman, R., Greenberg, S., Van Buchem, M., Stoops, E., Vanderstichele, H., Teunissen, C., Hankey, G., Wermer, M., Sohrabi, H., Martins, R. (2021). Plasma amyloid‐beta levels in a pre‐symptomatic dutch‐type hereditary cerebral amyloid angiopathy pedigree: A cross‐sectional and longitudinal investigation. International Journal of Molecular Sciences, 22(6), Article number 2931. https://doi.org/10.3390/ijms22062931.
  • Roe, J., Vidal-Piñeiro, D., Sørensen, ., Brandmaier, A., Düzel, S., Gonzalez, H., Kievit, R., Knights, E., Kühn, S., Lindenberger, U., Mowinckel, A., Nyberg, L., Park, D., Pudas, S., Rundle, M., Walhovd, K., Fjell, A., Westerhausen, R., Masters, C., Bush, A., Fowler, C., Darby, D., Pertile, K., Restrepo, C., Roberts, B., Robertson, J., Rumble, R., Ryan, T., Collins, S., Thai, C., Trounson, B., Lennon, K., Li, Q., Ugarte, F., Volitakis, I., Vovos, M., Williams, R., Baker, J., Russell, A., Peretti, M., Milicic, L., Lim, L., Rodrigues, M., Taddei, K., Taddei, T., Hone, E., Lim, F., Fernandez, S., Rainey-Smith, S., Pedrini, S., Martins, R., Doecke, J., Bourgeat, P., Fripp, J., Gibson, S., Leroux, H., Hanson, D., Dore, V., Zhang, P., Burnham, S., Rowe, C., Villemagne, V., Yates, P., Pejoska, S., Jones, G., Ames, D., Cyarto, E., Lautenschlager, N., Barnham, K., Cheng, L., Hill, A., Killeen, N., Maruff, P., Silbert, B., Brown, B., Sohrabi, H., Savage, G., Vacher, M. (2021). Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer’s disease. Nature Communications, 12(1), Article number 721. https://doi.org/10.1038/s41467-021-21057-y.

2020

Journal Articles

  • Chatterjee, P., Fernando, M., Fernando, B., Dias, C., Shah, T., Silva, R., Williams, S., Pedrini, S., Hillebrandt, H., Goozee, K., Barin, E., Sohrabi, H., Garg, M., Cunnane, S., Martins, R. (2020). Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer’s disease. Mechanisms of Ageing and Development, 186(March 2020), Article number 111209. https://doi.org/10.1016/j.mad.2020.111209.
  • Chatterjee, P., Mohammadi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Shen, K., Asih, P., Dave, P., Pedrini, S., Ashton, N., Hye, A., Taddei, K., Lovejoy, D., Zetterberg, H., Blennow, K., Martins, R. (2020). Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load. Journal of Alzheimer's Disease, 76(1), 291-301. https://doi.org/10.3233/JAD-200162.
  • Pedrini, S., Hone, E., Gupta, V., James, I., Teimouri, E., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Rainey-Smith, S., Verdile, G., Sohrabi, H., Raida, M., Wenk, M., Taddei, K., Chatterjee, P., Martins, I., Laws, S., Martins, R. (2020). Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance. Journal of Alzheimer's Disease, 77(2), 733-744. https://doi.org/10.3233/JAD-200291.

2019

Journal Articles

  • Chatterjee, P., Zetterberg, H., Goozee, K., Lim, C., Jacobs, K., Ashton, N., Hye, A., Pedrini, S., Sohrabi, H., Shah, T., Asih, P., Dave, P., Shen, K., Taddei, K., Lovejoy, D., Guillemin, G., Blennow, K., Martins, R. (2019). Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease. Journal of Neuroinflammation, 16(2019), Article number 186. https://doi.org/10.1186/s12974-019-1567-4.
  • Hata, S., Omori, C., Kimura, A., Saito, H., Kimura, N., Gupta, V., Pedrini, S., Hone, E., Chatterjee, P., Taddei, K., Kasuga, K., Ikeuchi, T., Waragai, M., Nishimura, M., Hu, A., Nakaya, T., Meijer, L., Maeda, M., Yamamoto, T., Masters, C., Rowe, C., Ames, D., Yamamoto, K., Martins, R., Gandy, S., Suzuki, T. (2019). Decrease in p3-Alcb37 and p3-Alcb40, products of Alcadein b generated by g-secretase cleavages, in aged monkeys and patients with Alzheimer’s disease. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5(1), 740-750. https://doi.org/10.1016/j.trci.2019.09.015.
  • Ashton, N., Nevado-Holgado, A., Barber, I., Lynham, S., Gupta, V., Chatterjee, P., Goozee, K., Hone, E., Pedrini, S., Blennow, K., Scholl, M., Zetterberg, H., Ellis, K., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Aarsland, D., Powell, J., Lovestone, S., Martins, R., Hye, A. (2019). A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease. Science Advances, 5(2), Article number eaau7220. https://doi.org/10.1126/sciadv.aau7220.
  • Chatterjee, P., Elmi, M., Goozee, K., Shah, T., Sohrabi, H., Dias, C., Pedrini, S., Shen, K., Asih, P., Dave, P., Taddei, K., Vanderstichele, H., Zetterberg, H., Blennow, K., Martins, R. (2019). Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease. Journal of Alzheimer's Disease, 71(3), 775-783. https://doi.org/10.3233/JAD-190533.

2018

Journal Articles

  • Martins, R., Villemagne, V., Sohrabi, H., Chatterjee, P., Shah, T., Verdile, G., Fraser, P., Taddei, K., Gupta, V., Rainey-Smith, S., Hone, E., Pedrini, S., Lim, F., Martins, I., Frost, S., Gupta, S., O'Bryant, S., Rembach, A., Ames, D., Ellis, K., Fuller, S., Brown, B., Kirby, S., Fernando, B., Bharadwaj, P., Burnham, S., Laws, S., Barron, A., Goozee, K., Wahjoepramono, EJ., Asih, P., Doecke, J., Salvado, O., Bush, A., Rowe, C., Gandy, S., Masters, C. (2018). Alzheimer’s Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies—Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease, 62(3), 965-992. https://doi.org/10.3233/JAD-171145.

2017

Journal Articles

  • Pedrini, S., Gupta, V., Hone, E., Doecke, J., O’bryant, S., James, I., Bush, AI., Rowe, CC., Villemagne, VL., Ames, D., Masters, CL., Martins, R. (2017). A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of beta-amyloid load in an AD cohort. Scientific Reports, 7(OCT 25 2017), Article number 14057. https://doi.org/10.1038/s41598-017-14020-9.
  • Gupta, V., Hone, E., Pedrini, S., Doecke, J., O'Bryant, S., James, I., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Martins, R. (2017). Altered levels of blood proteins in Alzheimer’s disease longitudinal study: Results from Australian Imaging Biomarkers lifestyle study of ageing cohort. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 8(2017), 60-72. https://doi.org/10.1016/j.dadm.2017.04.003.

2016

Journal Articles

  • Gupta, V., Doecke, J., Hone, E., Pedrini, S., Laws, S., Thambisetty, M., Bush, A., Rowe, C., Villemagne, V., Ames, D., Masters, C., Macaulay, SL., Rembach, A., Rainey-Smith, S., Martins, R. (2016). Plasma apolipoprotein J as a potential biomarker for Alzheimer's disease: Australian Imaging, Biomarkers and Lifestyle study of aging. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 3(2016), 18-26. https://doi.org/10.1016/j.dadm.2015.12.001.
  • Barr, R., Verdile, G., Wijaya, L., Morici, M., Taddei, K., Gupta, V., Pedrini, S., Jin, L., Nicolazzo, JA., Knock, E., Fraser, P., Martins, R. (2016). Validation and characterization of a novel peptide that binds monomeric and aggregated β-Amyloid and inhibits the formation of neurotoxic oligomers. Journal of Biological Chemistry, 291(2), 547-559. https://doi.org/10.1074/jbc.M115.679993.

2015

Journal Articles

  • Gupta, V., Wilson, A., Burnham, S., Hone, E., Pedrini, S., Laws, S., Lim, F., Rembach, A., Rainey-Smith, S., Ames, D., Cobiac, L., Macaulay, SL., Masters, C., Rowe, C., Bush, A., Martins, R. (2015). Follow-up plasma apolipoprotein E levels in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL) cohort. Alzheimer's Research and Therapy, 7(1), Article no.16. https://doi.org/10.1186/s13195-015-0105-6.

2013

Journal Articles

  • Tan, W., Naniche, N., Bogush, A., Pedrini, S., Trotti, D., Pasinelli, P. (2013). Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. Journal of Neuroscience, 33(28), 11588-11598. https://doi.org/10.1523/JNEUROSCI.5385-12.2013.

Research Projects

  • Analysis of neurofilament biomarkers for Alzheimer's disease, Parkinson's disease, Multiple sclerosis, and childhood dementia, National Foundation for Medical Research and Innovation, Alzheimer's Disease, 2023 ‑ 2025, $250,000.
  • Sponsorship of Research Fellow (multiple roles), Lions Alzheimer's Foundation, Sponsorship, 2022 ‑ 2024, $953,000.
  • Generation and Validation of 3 antibodies for the detection of GFAP isoforms for the diagnosis of preclinical Alzheimer’s Disease, Perron Institute for Neurological and Translational Science, Bryant Stokes Neurological Research Fund, 2024, $100,000.
  • Sponsorship of Research Fellows (multiple roles), Australian Alzheimer's Research Foundation, Australian Alzheimer's Research Foundation - Sponsorship, 2022 ‑ 2024, $1,480,000.
  • In-depth Neurofilament analysis as potential biomarkers for Alzheimer's Disease, National Foundation for Medical Research and Innovation, NFMRI - Grant, 2020 ‑ 2024, $170,000.
  • Sponsorship of Research Fellow (Eugene Hone, Prashant Bharadwaj, Steve Pedrini), Lions Alzheimer's Foundation, Sponsorship, 2021, $420,378.
  • Investigating beta amyloid-binding peptides as specific imaging agents for Alzheimers disease., Hollywood Private Hospital Research Foundation, Grant, 2015, $15,000.
  • Continuation of the 15M S.A work & In vitro testing of the Phylomers, Alzhyme Pty Ltd, Grant, 2015, $103,875.

Research Student Supervision

Current Supervisions

Associate Supervisor

  • Doctor of Philosophy, Development and Validation of an Ultrasensitive Single Molecule Array Digital Assay for Human Glial Fibrillary Acidic Protein (GFAP)

Completed Supervisions

No data available
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