Top of page

Student/Staff Portal
Global Site Navigation

School of Science

Local Section Navigation
You are here: Main Content
  • Liyan Chen

    Liyan Chen

Related Contents

Liyan Chen

Overview of thesis

My PhD research projects aim is to find a new method to protect liver in the period of liver surgery, which suffered by acute (ischemia and reperfusion (I/R)) injury. My PhD project is part of collaboration between ECU and Shantou University Medical College, Guangdong, China.

I/R injury in liver surgeries are associated with post-operative morbidity and mortality, and I/R injury as a major unresolved problem in clinical practice. The inflammasome plays an important role in the pathogenesis of liver I/R injury and has been identified as a major contributor to amplification of liver inflammation. Farnesoid X Receptor (FXR) is the master regulator of bile acid homeostasis and can inhibit Endoplasmic Reticulum (ER) stress-induced inflammasome activation in hepatocytes. Therefore, we hypothesise that if FXR can be activated in the early stages after hepatic surgery, it may reduce the effect of inflammation so as to reduce I/R injury and resultant post-operative morbidity and mortality.

Qualifications

  • Master Degree, Specialty of Surgery, Southern Medical University, Guangzhou, Guangdong, China (2010-2013)
  • Bachelor Degree, Specialty of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, China (2007-2010)
  • Regular Higher Education, Specialty of Clinical Medicine, Guangzhou medical University, Guangzhou, Guangdong, China (2003-2006)

Research

Research Interests

  • List these here
  • Analyse pathways of Laboratory Animal Science
  • Analyse the metabolites of liver tissue by Gas chromatography- Mass spectrometry (GC/MS), Liquid chromatography- Mass spectrometry (LC/MS) and (GC/LC-MS-MS).
  • Clinical Anatomy, Methods of Clinical Research

Past Research employment history

  • 2010 –2011: Study on the Subjects which relevant with the experiment, such as Biochemistry, analyze pathways of Laboratory Animal Science, analyze the metabolites of liver tissue by Gas chromatography- Mass spectrometry (GC/MS), Clinical Anatomy, Methods of Clinical Research. Etc.
  • 2012- 2013: Worked in the labs of Southern Medical University Hospital and Southern Medical University. Complete the study on constructed SD Rat model of Pringle Meneuver, then extract the serum, liver tissues and urine on Serology, HE staining and GC-MS. published the paper in 2013.
  • Published paper, title: ‘Detection of Urinary Metabolomics before and after Pringle maneuver-Induced Liver Ischemia and Reperfusion Injury in Rats Using Gas Chromatography-Mass Spectrometry’ on <Disease Marker> in 2013. IF: 2.14.

Other work

  • Year-Year: Position, location
  • 2010 - 2012: As a surgeon worked in the department of Hepatological Surgery, Nanfang Hospital,Southern Medical University. Major subject: Liver transplantation, tumor of liver segment, gallstone surgery, etc.
  • 2013 –2019: As a surgeon worked in the Department of Hepatological Surgery, Second Affiliate Hospital, Shantou University Medical College (STMC).

Scholarships and Awards

  • 2010 - Science and technology special project of Guangdong Province, China

Supervisors

Principal Supervisor: Dr Hayley ABBISS
Co-Principal Supervisor: Dr Ari SHAFAEI DARESTANI
Associate Supervisor: Prof David BROADHURST

Contact

Liyan Chen
PhD Student
School of Science
Skip to top of page