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    • Dr Armaghan Shafaei Darestani
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    • Dr Armaghan Shafaei Darestani

      Dr Armaghan Shafaei Darestani

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Dr Armaghan Shafaei Darestani

Lecturer

Staff Member Details
Telephone: +61 8 6304 5952
Email: a.shafaeidarestani@ecu.edu.au
Campus: Joondalup  
Room: JO19.364  
ORCID iD: https://orcid.org/0000-0002-5763-531X

Armaghan is a Research Fellow with the Centre of Integrative Metabolomics & Computational Biology (CIMCB) in the School of Science.

Current Teaching

  • SCC2211 Organic Chemistry
  • SCC3201 Analytical Chemistry

Background

Armaghan Shafaei received her PhD in Pharmaceutical Chemistry. Her PhD research focused on applying analytical chemistry to investigate bioactivity, safety and efficacy of medicinal plants for treating different diseases such as hypertension, cancer, obesity and uterine fibroid. During her Endeavour Postdoctoral Fellowship (awarded by the Australian Government Department of Education and Training) she linked the analytical research with metabolomic, nutrition and epidemiology expertise. In particular, she developed targeted assays using liquid chromatography-mass spectrometry (LC-MS) techniques for identification and quantification of different metabolites in human plasma and urine samples to support dietary intervention studies. More recently, as a Postdoctoral Fellow at Norwegian University of Science and Technology (NTNU), her research foci were on the development of a suite of targeted and non-targeted Metabolomics and Proteomics methods, applicable to a range of biological model systems (prokaryotic and eukaryotic) for deep phenotyping of model systems.

Professional Memberships

  • 2010 - Malaysian Natural Product Society, MNPS (Member)
  • 2020 – International Metabolomics Society

Awards and Recognition

National and International Awards

  • 2018 - Endeavour Postdoctoral Research Fellowship (Australian Government Department of Education and Training)
  • 2014 - Gold medal for the invention of an anti-hypertension medicine based on local plants in the 25th international invention, innovation & technology exhibition (ITEX 2014), Kuala Lumpur, Malaysia
  • PhD Research Fellowship (University of Science Malaysia)

National and International Research Positions

  • 2019 – Postdoctoral Fellow, held at Norwegian University of Science and Technology (Trondheim, Norway)
  • 2018 – Postdoctoral Research Fellow, held at the University of Western Australia and Edith Cowan University (Australia)

Research Areas and Interests

  • Analytical chemistry
  • Nutritional metabolomics
  • Clinical and biomedical metabolomics

Qualifications

  • Doctor of Philosophy, Malaysia, 2017.

Research Outputs

2024

Journal Articles

  • Senavirathna, T., Shafaei Darestani, A., Lareu, R., Balmer, L. (2024). Unlocking the Therapeutic Potential of Ellagic Acid for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis. Antioxidants, 13(4), Article number 485. https://doi.org/10.3390/antiox13040485.
  • Hill, C., Shafaei Darestani, A., Matthews, VB., Ward, NC., Croft, KD., Lewis, J., Hodgson, J., Balmer, L., Blekkenhorst, L. (2024). S-Methyl Cysteine Sulfoxide Does Not Ameliorate Weight Gain or Hyperlipidemia in Mice Fed a High-Fat Diet. Molecular Nutrition & Food Research, 68(10), article number 2400034. https://doi.org/10.1002/mnfr.202400034.
  • Hill, C., Connolly, E., Shafaei Darestani, A., Balmer, L., Zhong, L., Muka, T., Hayhoe, A., Saha, S., Woodman, RJ., Lewis, J., Hodgson, J., Blekkenhorst, L. (2024). Development of a food composition database for the estimation of dietary S-methyl cysteine sulfoxide from vegetables. Journal of Food Composition and Analysis, 130(2024), article number 106151. https://doi.org/10.1016/j.jfca.2024.106151.
  • Connolly, E., Liu, A., Radavelli Bagatini, S., Shafaei Darestani, A., Boyce, M., Wood, LG., McCahon, L., Koch, H., Sim, M., Hill, C., Parmenter, B., Bondonno, N., Devine, A., Croft, KD., Mithen, R., Gan, SK., Schultz, CJ., Woodman, RJ., Bondonno, C., Lewis, J., Hodgson, J., Blekkenhorst, L. (2024). Cruciferous vegetables lower blood pressure in adults with mildly elevated blood pressure in a randomized, controlled, crossover trial: the VEgetableS for vaScular hEaLth (VESSEL) study. BMC Medicine, 22(1), article number 353. https://doi.org/10.1186/s12916-024-03577-8.
  • Shafaei Darestani, A., Hill, C., Hodgson, J., Blekkenhorst, L., Boyce, M. (2024). Simultaneous extraction and quantitative analysis of S-Methyl-L-Cysteine Sulfoxide, sulforaphane and glucosinolates in cruciferous vegetables by liquid chromatography mass spectrometry. Food Chemistry: X, 21(2024), article number 101065. https://doi.org/10.1016/j.fochx.2023.101065.
  • Abbiss, H., Shafaei Darestani, A., Bannister, M., Boyce, M. (2024). Quantitative Determination of Short Chain Fatty Acids in Synthetic Feces Using Gas Chromatography with Flame Ionization Detection or Mass Spectrometry. Journal of Chemical Education, 101(1), 113-119. https://doi.org/10.1021/acs.jchemed.3c00340.

2023

Journal Articles

  • Hill, C., Liu, A., McCahon, L., Zhong, L., Shafaei Darestani, A., Balmer, L., Lewis, J., Hodgson, J., Blekkenhorst, L. (2023). S-methyl cysteine sulfoxide and its potential role in human health: a scoping review. Critical Reviews in Food Science and Nutrition, 2023(Article in press), TBD. https://doi.org/10.1080/10408398.2023.2267133.

2022

Journal Articles

  • Shafaei Darestani, A., Abbiss, H., Coutts, S., Bannister, M., Bruemmer, J., Boyce, M. (2022). Tocopherols in Seeds and Nuts: QuEChERS Extraction, HPLC Separation, and Fluorescence Detection. Journal of Chemical Education, 99(5), 2093-2100. https://doi.org/10.1021/acs.jchemed.1c01203.
  • Hill, C., Shafaei Darestani, A., Balmer, L., Lewis, J., Hodgson, J., Millar, H., Blekkenhorst, L. (2022). Sulfer compounds: From plants to humans and their role in chronic disease prevention.. Critical Reviews in Food Science and Nutrition, 2022(article in press), 1-23. https://doi.org/10.1080/10408398.2022.2057915.

2021

Journal Articles

  • Shafaei Darestani, A., Vamathevan, VV., Pandohee, J., Lawler, N., Broadhurst, D., Boyce, M. (2021). Sensitive and quantitative determination of short-chain fatty acids in human serum using liquid chromatography mass spectrometry. Analytical and Bioanalytical Chemistry, 413(25), 6333-6342. https://doi.org/10.1007/s00216-021-03589-w.
  • Shafaei Darestani, A., Rees, J., Christophersen, C., Devine, A., Broadhurst, D., Boyce, M. (2021). Extraction and quantitative determination of bile acids in feces. Analytica Chimica Acta, 1150(15 March 2021), Article 338224. https://doi.org/10.1016/j.aca.2021.338224.
  • Shafaei Darestani, A., Sostaric, T., Bruemmer, J., Blake, D., Sanfead, T., Unlu, H., Lagesse, H., Boyce, M. (2021). Development of a high-performance thin-layer chromatography method for the analysis of Kakadu plum. Journal of Planar Chromatography: Modern TLC, 34(1), 89-94. https://doi.org/10.1007/s00764-021-00081-0.

2020

Journal Articles

  • Røst, LM., Shafaei Darestani, A., Fuchino, K., Bruheim, P. (2020). Zwitterionic HILIC tandem mass spectrometry with isotope dilution for rapid, sensitive and robust quantification of pyridine nucleotides in biological extracts. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1144(1 May 2020), Article number 122078. https://doi.org/10.1016/j.jchromb.2020.122078.
  • Zakaria, N., Mohd, KS., Saeed, MA., Hassan, LE., Shafaei Darestani, A., Al-Suede, FS., Memon, AH., Ismail, Z. (2020). Anti-Uterine Fibroid Effect of Standardized Labisia Pumila Var. Alata Extracts In Vitro and in Human Uterine Fibroid Cancer Xenograft Model. Asian Pacific Journal of Cancer Prevention (APJCP), 21(4), 943-951. https://doi.org/10.31557/APJCP.2020.21.4.943.
  • Jafaria, SF., Al-Suede, FS., Yehya, AH., Ahamed, MB., Shafaei Darestani, A., Asif, M., Tabana, YM., Majid, AM., Baharetha, HM. (2020). Pharmacokinetics and antiangiogenic studies of potassium koetjapate in rats. Biomedicine and Pharmacotherapy, 130(October 2020), Article number 110602. https://doi.org/10.1016/j.biopha.2020.110602.
  • Bondonno, C., Bondonno, N., Shinde, S., Shafaei Darestani, A., Boyce, M., Swinny, E., Jacob, S., Lacey, K., Woodman, R., Croft, K., Considine, M., Hodgson, J. (2020). Phenolic composition of 91 Australian apple varieties: towards understanding their health attributes. Food and Function, 11(8), 7115-7125. https://doi.org/10.1039/d0fo01130d.

2019

Journal Articles

  • Esmailli, K., Shafaei Darestani, A., Aisha, A., Al-Suede, F., Majid, A., Ismail, Z. (2019). Evaluation of in vitro cytotoxicity effect of Clinacanthus nutans (Brum. f.) Lindau standardized leaf extracts. Tropical Journal of Pharmaceutical Research, 18(11), 2341-2348. https://doi.org/10.4314/tjpr.v18i11.16.
  • Muhammad, A., Yehya, AH., Dahham, SS., Mohamed, S., Shafaei Darestani, A., Oday Ezzatf, M., Abdul Majid, AS., Oon, CE., Abdul Majid, AM. (2019). Establishment of in vitro and in vivo anti-colon cancer efficacy of essential oils containing oleo-gum resin extract of Mesua ferrea. Biomedicine and Pharmacotherapy, 109(January 2019), 1620-1629. https://doi.org/10.1016/j.biopha.2018.10.127.
  • Le, TT., Shafaei Darestani, A., Genoni, A., Christophersen, C., Devine, A., Lo, J., Lyons-Wall, P., Boyce, M. (2019). Development and validation of a simple LC-MS/MS method for the simultaneous quantitative determination of trimethylamine-N-oxide and branched chain amino acids in human serum. Analytical and Bioanalytical Chemistry, 411(5), 1019–1028. https://doi.org/10.1007/s00216-018-1522-8.
  • Shafaei Darestani, A., Croft, K., Hodgson, J., Boyce, M. (2019). Simultaneous quantitative analysis of polyphenolic compounds in human plasma by liquid chromatography tandem mass spectrometry. Journal of Separation Science, 42(18), 2909-2921. https://doi.org/10.1002/jssc.201900339.

2018

Journal Articles

  • Shafaei Darestani, A., A. Saeed, MA., R. Hami, MS., Ismail, Z. (2018). Application of High Performance Liquid Chromatography and Fourier-Transform Infrared Spectroscopy Techniques for Evaluating the Stability of Orthosiphon stamineus Ethanolic Extract and Its Nano Liposomes. Brazilian Journal of Pharmacognsosy, 28(6), 658-668. https://doi.org/10.1016/j.bjp.2018.07.005.

2017

Journal Articles

  • Asif, M., Shafaei Darestani, A., Abdul Majid, AS., Ezzat, MO., Dahham, SS., Ahamed, MB., Oon, CE., Abdul Majid, AM. (2017). Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways. Chinese Journal of Natural Medicines, 15(7), 505-514. https://doi.org/10.1016/S1875-5364(17)30076-6.
  • Shafaei Darestani, A., Ab Halim, NH., Zakaria, N., Ismail, Z. (2017). Analysis of Free Amino Acids in Different Extracts of Orthosiphon stamineus Leaves by High-Performance Liquid Chromatography Combined with Solid-Phase Extraction. Pharmacognosy Magazine, 13(51), S385-S391. https://doi.org/10.4103/0973-1296.216337.
  • Shafaei Darestani, A., Ahmad Saeed, MA., Aisha, AF., Ismail, Z. (2017). Pharmacokinetics and Bioavailability of Orthosiphon stamineus Ethanolic Extract and its Nano Liposomes in Sprague Dawley Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 9(1), 199-206. https://doi.org/10.22159/ijpps.2017v9i1.12407.

2016

Journal Articles

  • Shafaei Darestani, A., Sultan Khan, MS., Aisha , AF., Majid , AM., Hamdan, MR., Mordi , MN., Ismail, Z. (2016). Flavonoids-rich Orthosiphon stamineus Extract as New Candidate for Angiotensin I-Converting Enzyme Inhibition: A Molecular Docking Study. Molecules, 21(11), Article number 1500. https://doi.org/10.3390/molecules21111500.
  • Farsi, E., Esmailli, K., Shafaei Darestani, A., Moradi Khaniabadi, P., Al Hindi, B., Ahamed, MB., Sandai, D., Abdul Sattar, M., Ismail, Z., Abdul Majid, AM., Abdul Majid, AS. (2016). Mutagenicity and Preclinical Safety Assessment of The Aqueous Extract of Clinacanthus nutans Leaves. Drug and Chemical Toxicology: an international journal for rapid communication, 39(4), 461-473. https://doi.org/10.3109/01480545.2016.1157810.
  • Farsi, E., Esmailli, K., Shafaei Darestani, A., Ahamed, MB., Abdul Majid, AS., Abdul Sattar, MZ., Abdul Majid, AM. (2016). Preclinical safety assessment and mutagenicity of the hydroethanolic extract of Syzygium campanulatum leaves. International Journal of Phytomedicine, 8(4), 514-524. https://doi.org/10.5138/09750185.1955.
  • Muhammad, A., Shafaei Darestani, A., Jafari, SF., Mohamed, SK., Ezzat, MO., Abdul Majid, AS., Oon, CE., Petersen, SH., Kono, K., Abdul Majid, AM. (2016). Isoledene from Mesua ferrea oleo-gum resin induces apoptosis in HCT 116 cells through ROS-mediated modulation of multiple proteins in the apoptotic pathways: A mechanistic study. Toxicology Letters, 257(22 August 2016), 84-96. https://doi.org/10.1016/j.toxlet.2016.05.027.

2015

Journal Articles

  • Shafaei Darestani, A., Esmailli, K., Farsi, E., Aisha, AF., Abul Majid, AM., Ismail, Z. (2015). Genotoxicity, acute and subchronic toxicity studies of nano liposomes of Orthosiphon stamineus ethanolic extract in Sprague Dawley rats. BMC Complementary and Alternative Medicine, 360(15), 1-14. https://doi.org/10.1186/s12906-015-0885-z.
  • Shafaei Darestani, A., Aisha, AF., Ahmad Siddiqui, MJ., Ismail, Z. (2015). Analysis of L-Citrulline and L-Arginine in Ficus deltoidea Leaf Extracts by Reverse Phase High Performance Liquid Chromatography. Pharmacognosy Research, 7(1), 32-37. https://doi.org/10.4103/0974-8490.147196.

2014

Journal Articles

  • Shafaei Darestani, A., Muslim, NS., Nassar, ZD., Aisha, AF., Abdul Majid, AM., Ismail, Z. (2014). Antiangiogenic Effect of Ficus deltoidea Jack Standardised Leaf Extracts. Tropical Journal of Pharmaceutical Research, 13(5), 761-768. https://doi.org/10.4314/tjpr.v13i5.16.

2013

Journal Articles

  • Farsi, E., Shafaei Darestani, A., Hor, SY., Ahamed, MB., Yam, MF., Asmawi, MZ., Ismail, Z. (2013). Genotoxicity and acute and subchronic toxicity studies of a standardized methanolic extract of ficus deltoidea leaves. Clinics, 68(6), 865-875. https://doi.org/10.6061/clinics/2013(06)23.

2012

Journal Articles

  • Muslim, NS., Nassar, ZD., Aisha, AF., Shafaei Darestani, A., Idris, N., Abdul Majid, AM., Ismail, Z. (2012). Antiangiogenesis and Antioxidant Activity of Ethanol Extracts of Pithecellobium Jiringa. BMC Complementary and Alternative Medicine, 12(5 November 2012), Article number 1171. https://doi.org/10.1186/1472-6882-12-210.
  • Shafaei Darestani, A., Farsi, E., Ismail, Z., Asmawi, MZ. (2012). Quantitative High Performance Thin-Layer Chromatography Method for Analysis of Vitexin and Isovitexin in Extracts of Leaves of Ficus deltoidea. Asian Journal of Chemistry: an international peer reviewed research journal of chemistry, 24(5), 2283-2286.

2011

Journal Articles

  • Shafaei Darestani, A., Farsi, E., Khadeer Ahamed, B., Ahmad Siddiqui, MJ., Attitalla, IH., Zhari, I., Asmawi, MZ. (2011). Evaluation of toxicological and standardization parameters and phytochemical investigation of Ficus deltoidea leaves. American Journal of Biochemistry and Molecular Biology, 1(3), 237-243. https://doi.org/10.3923/ajbmb.2011.237.243.
  • Farsi, E., Shafaei Darestani, A., Hor, SY., Ahamed, MB., Yam, M., Attitalla, IH., Asmawi, MZ., Ismail, Z. (2011). Correlation between enzymes inhibitory effects and antioxidant activities of standardized fractions of methanolic extract obtained from Ficus deltoidea leaves. African Journal of Biotechnology, 10(67), 15184-15194. https://doi.org/10.5897/AJB11.1365.

Research Projects

  • Development of a Routine Forensic Process for Individual Identification using Genetically Variant Peptides in Human Hair Evidence , Chemistry Centre WA T/A ChemCentre, Top Up Scholarship, 2022 ‑ 2026, $52,500.
  • Exploring the health effects of S-methyl cysteine sulfoxide for the prevention of type 2 diabetes, Edith Cowan University, Early-Mid Career Researcher Grant Scheme 2022 (Stream 2), 2023 ‑ 2024, $39,511.
  • Metabolomics for Asthma Prediction 2 (MAP-2), Perth Children's Hospital, Grant, 2023 ‑ 2024, $243,343.
  • Sponsorship Agreement for Research Fellow in Analytical Chemistry/Proteomics, Chemistry Centre WA T/A ChemCentre, Research Fellowship Grant, 2017 ‑ 2023, $701,666.

Research Student Supervision

Current Supervisions

Principal Supervisor

  • Master of Science by Research, Development and validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of an array of bile acids in human plasma samples to better understand irritable bowel syndrome

Co-principal Supervisor

  • Doctor of Philosophy, Investigation of metabolite biomarkers for early, minimally invasive detection of polycystic kidney disease.

Associate Supervisor

  • Doctor of Philosophy, Development of a Routine Forensic Process for Individual Identification using Genetically Variant Peptides in Human Hair Evidence
  • Doctor of Philosophy, Efficacy of ellagic acid and its microbial metabolites in a diet-induced mouse model of non-alcoholic steatohepatitis (NASH)
  • Master of Science by Research, Development of a GC-MS Method to Extract and Quantify Gamma Hydroxybutyrate from Hair to Assist Forensic Investigation

Completed Supervisions

Associate Supervisor

  • Doctor of Philosophy, Diet quality and mental health: how does improved cooking confidence after a food literacy cooking program affect mental health outcomes and associations with dietary and gut biomarkers of the gut-brain axis.?
  • Doctor of Philosophy, Dietary S-methyl cysteine sulfoxide and human health: Mechanisms of action and cardiometabolic effects.
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